抗过氧化亚硝酸盐损伤的胸腺嘧啶单磷酸抗体对系统性红斑狼疮患者疾病活动的影响。

Impact of anti-peroxynitrite-damaged-thymidine-monophosphate antibodies on disease activity in patients with systemic lupus erythematosus.

作者信息

Alghasham Abdullah, Al Salloom Abdulaziz A M, Alghamadi Ahmed S S, Rasheed Zafar

机构信息

a Department of Pharmacology and Therapeutics, College of Medicine , Qassim University , Buraidah , KSA.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2015;34(1):56-68. doi: 10.1080/15257770.2014.958235.

DOI:10.1080/15257770.2014.958235

PMID:25513864

Abstract

Present study probes the role of peroxynitrite (ONOO(-))-modified thymidine-5'-monophosphate (TMP) in SLE patients with different disease activity scores according to the SLE Disease Activity Index (SLEDAI). Serum analysis showed significant increased number of subjects positive for anti-ONOO(-)-TMP-protein antibodies in SLE patients with different SLEDAI scores. Interestingly, the levels of these antibodies were significantly higher among SLE patients, whose SLEDAI scores were ≥20. In addition, a significant correlation was observed between the levels of anti-ONOO(-)-TMP-protein antibodies and the SLEDAI score (r = 0.595, p < 0.0001). In short, this study shows a positive association between anti-ONOO(-)-TMP-protein antibodies and SLEDAI. The stronger response observed in patients with higher SLEDAI scores suggests that anti-ONOO(-)-TMP-protein antibodies may be useful in evaluating the progression of SLE and in elucidating the mechanisms of disease pathogenesis.

摘要

本研究根据系统性红斑狼疮疾病活动指数（SLEDAI），探讨过氧亚硝酸盐（ONOO(-)）修饰的胸腺嘧啶核苷-5'-单磷酸（TMP）在不同疾病活动评分的系统性红斑狼疮（SLE）患者中的作用。血清分析显示，不同SLEDAI评分的SLE患者中，抗ONOO(-)-TMP-蛋白抗体阳性的受试者数量显著增加。有趣的是，在SLEDAI评分≥20的SLE患者中，这些抗体的水平显著更高。此外，抗ONOO(-)-TMP-蛋白抗体水平与SLEDAI评分之间存在显著相关性（r = 0.595，p < 0.0001）。简而言之，本研究表明抗ONOO(-)-TMP-蛋白抗体与SLEDAI之间存在正相关。在SLEDAI评分较高的患者中观察到更强的反应，这表明抗ONOO(-)-TMP-蛋白抗体可能有助于评估SLE的进展并阐明疾病发病机制。