DeMet E M, Chicz-DeMet A, Fleischmann J
Department of Psychiatry and Human Behavior, University of California, Irvine 92717.
Biol Psychiatry. 1989 Sep;26(5):489-95. doi: 10.1016/0006-3223(89)90069-3.
The densities of platelet 3H-imipramine sites were determined by repetitive measures of 11 normal controls over the course of 1 year. A significant seasonal variation was found, with a circannual peak on February 17 and a nadir on August 18. The estimated amplitude of this rhythm was +/- 599.54 fmol/mg, which fluctuated about a yearly mean of 2647.5 fmol/mg. The present results underscore the importance of including seasonally matched controls in the evaluation of potential patient differences in platelet binding.
通过对11名正常对照者在1年时间内的重复测量，测定血小板3H-丙咪嗪位点的密度。发现存在显著的季节性变化，2月17日出现年周期高峰，8月18日出现最低点。这种节律的估计振幅为±599.54 fmol/mg，围绕每年2647.5 fmol/mg的平均值波动。目前的结果强调了在评估血小板结合潜在患者差异时纳入季节匹配对照的重要性。
