Galzin A M, Lôo H, Sechter D, Langer S Z
Biol Psychiatry. 1986 Aug;21(10):876-82. doi: 10.1016/0006-3223(86)90260-x.
The Bmax of [3H]imipramine (IMI) binding has been reported to be reduced in platelets of depressed untreated patients as compared with normal controls. However, it has also been suggested that this difference could be related to the failure to take into account seasonal variations in the binding parameters for [3H]IMI recognition sites in platelets. For this reason, [3H]IMI binding was studied throughout 1 year in platelet membranes from 11 control volunteers, with blood samples collected once a month. The Bmax and Kd values of [3H]IMI binding showed no significant variation throughout the 12-month period of the study. These results indicate that in the control population, the platelet [3H]IMI binding parameters remain stable, and that the decrease in Bmax observed in depressed untreated patients reflects a genuine difference, which may be considered to be a biological marker in depression.
据报道，与正常对照组相比，未经治疗的抑郁症患者血小板中[3H]丙咪嗪（IMI）结合的最大结合量（Bmax）降低。然而，也有人提出，这种差异可能与未考虑血小板中[3H]IMI识别位点结合参数的季节性变化有关。因此，对11名对照志愿者的血小板膜进行了为期1年的[3H]IMI结合研究，每月采集一次血样。在研究的12个月期间，[3H]IMI结合的Bmax和解离常数（Kd）值没有显著变化。这些结果表明，在对照人群中，血小板[3H]IMI结合参数保持稳定，并且在未经治疗的抑郁症患者中观察到的Bmax降低反映了一种真正的差异，这可能被认为是抑郁症的一种生物学标志物。
