Abenavoli Ludovico, Peta Valentina
Department of Health Sciences, University "Magna Græcia", Viale Europa, 88100, Catanzaro, Italy.
Rev Recent Clin Trials. 2014;9(3):134-40. doi: 10.2174/1574887109666141216102458.
One of the most common hepatic manifestations of the metabolic syndrome is non-alcoholic fatty liver disease (NAFLD). This disease varies from simple steatosis to cirrhosis and hepatocellular carcinoma. Different molecules secreted from adipose tissue such as adiponectin, leptin, resistin and visfatin and pro-inflammatory cytokines such as tumour necrosis factor-α, and interleukins, can be involved in the pathogenesis of NAFLD. In this review we describe the role of these adipokines and cytokines in the pathogenesis of NAFLD. We comment on their potential use as non-invasive biomarkers of steatosis and fibrosis, and their potential therapeutic role.
代谢综合征最常见的肝脏表现之一是非酒精性脂肪性肝病（NAFLD）。这种疾病范围从单纯性脂肪变性到肝硬化和肝细胞癌。脂肪组织分泌的不同分子，如脂联素、瘦素、抵抗素和内脂素，以及促炎细胞因子，如肿瘤坏死因子-α和白细胞介素，都可能参与NAFLD的发病机制。在本综述中，我们描述了这些脂肪因子和细胞因子在NAFLD发病机制中的作用。我们评论了它们作为脂肪变性和纤维化的非侵入性生物标志物的潜在用途及其潜在的治疗作用。
