Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, India.
FEBS J. 2015 Feb;282(4):732-45. doi: 10.1111/febs.13178. Epub 2015 Jan 8.
Membrane-active peptides can be classified as cell-penetrating peptides and antimicrobial peptides (AMPs) that are known to play interchangeable roles. In this study, this dual behaviour was studied for the marine AMP, tachyplesin. It is a well-established cyclic peptide known to possess antimicrobial properties and was investigated for its cell-penetrating property and cargo delivery ability. Because of its derivation from a marine organism as well as cyclic nature, it has been shown to possess higher stability in vitro. In this study, its internalization as a cell-penetrating peptide was established and characterized in both plant and mammalian systems. It was shown to deliver cargo molecules in both living systems, emerging as an efficient nonviral macromolecule nanocarrier.
膜活性肽可分为细胞穿透肽和抗菌肽 (AMPs)，它们已知可发挥可互换的作用。在这项研究中，研究了海洋 AMP，缩胆囊素的这种双重行为。它是一种众所周知的具有抗菌特性的环状肽，并研究了其细胞穿透特性和货物输送能力。由于它源自海洋生物并且具有环状性质，因此已显示出在体外具有更高的稳定性。在这项研究中，它作为细胞穿透肽的内化在植物和哺乳动物系统中得到了确立和表征。它被证明可以在这两种生物系统中输送货物分子，成为一种有效的非病毒大分子纳米载体。
