Warnert Esther A H, Murphy Kevin, Hall Judith E, Wise Richard G
Cardiff University Brain Research and Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK.
Department of Anaesthetics and Intensive Care Medicine, School of Medicine, Cardiff University, Cardiff, UK.
J Cereb Blood Flow Metab. 2015 Mar;35(3):461-8. doi: 10.1038/jcbfm.2014.219. Epub 2014 Dec 17.
A noninvasive method of assessing cerebral arterial compliance (AC) is introduced in which arterial spin labeling (ASL) is used to measure changes in arterial blood volume (aBV) occurring within the cardiac cycle. Short inversion time pulsed ASL (PASL) was performed in healthy volunteers with inversion times ranging from 250 to 850 ms. A model of the arterial input function was used to obtain the cerebral aBV. Results indicate that aBV depends on the cardiac phase of the arteries in the imaging volume. Cerebral AC, estimated from aBV and brachial blood pressure measured noninvasively in systole and diastole, was assessed in the flow territories of the basal cerebral arteries originating from the circle of Willis: right and left middle cerebral arteries (RMCA and LMCA), right and left posterior cerebral arteries (RPCA and LPCA), and the anterior cerebral artery (ACA). Group average AC values calculated for the RMCA, LMCA, ACA, RPCA, and LPCA were 0.56%±0.2%, 0.50%±0.3%, 0.4%±0.2%, 1.1%±0.5%, and 1.1%±0.3% per mm Hg, respectively. The current experiment has shown the feasibility of measuring AC of cerebral arteries with short inversion time PASL.
介绍了一种评估脑动脉顺应性（AC）的无创方法，该方法利用动脉自旋标记（ASL）来测量心动周期内动脉血容量（aBV）的变化。对健康志愿者进行了短反转时间脉冲ASL（PASL）检查，反转时间范围为250至850毫秒。使用动脉输入函数模型来获取脑aBV。结果表明，aBV取决于成像区域内动脉的心动周期阶段。根据在收缩期和舒张期无创测量的aBV和肱动脉血压评估了源自Willis环的脑基底动脉血流区域的脑AC：右侧和左侧大脑中动脉（RMCA和LMCA）、右侧和左侧大脑后动脉（RPCA和LPCA）以及大脑前动脉（ACA）。为RMCA、LMCA、ACA、RPCA和LPCA计算的组平均AC值分别为每毫米汞柱0.56%±0.2%、0.50%±0.3%、0.4%±0.2%、1.1%±0.5%和1.1%±0.3%。当前实验已证明使用短反转时间PASL测量脑动脉AC的可行性。
