Yamamoto Junpei, Yamane Takumi, Oishi Yuichi, Kobayashi-Hattori Kazuo
a Faculty of Applied Bioscience, Department of Nutritional Science , Tokyo University of Agriculture , Tokyo , Japan.
Biosci Biotechnol Biochem. 2015;79(4):636-9. doi: 10.1080/09168451.2014.991683. Epub 2014 Dec 17.
We examined the effect of perfluorooctanoic acid (PFOA) on adipose cells using 3T3-L1 adipocytes and found that PFOA increased adipocyte differentiation, triglyceride accumulation, and the mRNA level of factors related to adipocyte differentiation. In addition, PFOA bound to peroxisome proliferator-activated receptor γ (PPAR γ). These results suggest that PFOA promotes adipocyte differentiation as a PPAR γ ligand.
我们使用3T3-L1脂肪细胞研究了全氟辛酸(PFOA)对脂肪细胞的影响,发现PFOA增加了脂肪细胞分化、甘油三酯积累以及与脂肪细胞分化相关因子的mRNA水平。此外,PFOA与过氧化物酶体增殖物激活受体γ(PPARγ)结合。这些结果表明,PFOA作为一种PPARγ配体促进脂肪细胞分化。