Peeters Theo L
Gut Peptide Laboratory, Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium.
Curr Opin Endocrinol Diabetes Obes. 2015 Feb;22(1):9-13. doi: 10.1097/MED.0000000000000123.
To summarize the recent findings.
Studies of changes in the plasma levels confirm the earlier concepts, but offer little proof of causal effect. It is increasingly realized that peptides produced in the gut have a paracrine role or an indirect effect via the gut-brain axis. Interest in prokinetic peptide agonists remains high despite the failure of two candidate drugs, but relamorelin and camicinal offer new hope.
We review the original studies published since January 2013 on peptides produced in the gut and with an effect on gastrointestinal motility.
总结近期研究结果。
血浆水平变化的研究证实了早期的概念，但几乎没有因果效应的证据。人们越来越认识到肠道产生的肽具有旁分泌作用或通过肠-脑轴产生间接效应。尽管两种候选药物试验失败，但对促动力肽激动剂的兴趣仍然很高，而瑞莫瑞林和卡米西平带来了新的希望。
我们回顾了自2013年1月以来发表的关于肠道产生的、对胃肠动力有影响的肽的原始研究。
