Rolim Thaís de Souza, Fabri Gisele Maria Campos, Nitrini Ricardo, Anghinah Renato, Teixeira Manoel Jacobsen, Siqueira José Tadeu T de, Cesari José Augusto Ferrari, Siqueira Silvia Regina Dowgan Tesseroli de
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
Divisão de Odontologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
Arq Neuropsiquiatr. 2014 Dec;72(12):919-24. doi: 10.1590/0004-282X20140140.
Oral infections may play a role in Alzheimer's disease (AD). Objective To describe the orofacial pain, dental characteristics and associated factors in patients with Alzheimer's Disease that underwent dental treatment. Method 29 patients with mild AD diagnosed by a neurologist were included. They fulfilled the Mini Mental State Exam and Pfeffer's questionnaire. A dentist performed a complete evaluation: clinical questionnaire; research diagnostic criteria for temporomandibular disorders; McGill pain questionnaire; oral health impact profile; decayed, missing and filled teeth index; and complete periodontal investigation. The protocol was applied before and after the dental treatment. Periodontal treatments (scaling), extractions and topic nystatin were the most frequent. Results There was a reduction in pain frequency (p=0.014), mandibular functional limitations (p=0.011) and periodontal indexes (p<0.05), and an improvement in quality of life (p=0.009) and functional impairment due to cognitive compromise (p<0.001) after the dental treatment. Orofacial complaints and intensity of pain also diminished. Conclusion The dental treatment contributed to reduce co-morbidities associated with AD and should be routinely included in the assessment of these patients.
口腔感染可能在阿尔茨海默病（AD）中起作用。目的描述接受牙科治疗的阿尔茨海默病患者的口面部疼痛、牙齿特征及相关因素。方法纳入29例经神经科医生诊断为轻度AD的患者。他们完成了简易精神状态检查表和 Pfeffer问卷。一名牙医进行了全面评估：临床问卷；颞下颌关节紊乱研究诊断标准；麦吉尔疼痛问卷；口腔健康影响概况；龋失补牙指数；以及完整的牙周检查。该方案在牙科治疗前后应用。牙周治疗（洁治）、拔牙和局部使用制霉菌素是最常见的治疗方法。结果牙科治疗后，疼痛频率（p = 0.014）、下颌功能受限（p = 0.011）和牙周指数（p < 0.05）降低，生活质量（p = 0.009）和认知功能损害导致的功能障碍（p < 0.001）得到改善。口面部不适和疼痛强度也有所减轻。结论牙科治疗有助于减少与AD相关的合并症，应常规纳入这些患者的评估中。
