Singh Satnam, Schwarz Konstantin, Horowitz John, Frenneaux Michael
From the Department of Cardiovascular Medicine, University of Aberdeen, Aberdeen, United Kingdom (S.S., K.S., M.F.); and Cardiology Unit, The Queen Elizabeth Hospital, Adelaide, Australia (J.H.).
Circ Cardiovasc Genet. 2014 Oct;7(5):720-8. doi: 10.1161/CIRCGENETICS.114.000221.
Cardiac energetic impairment is a frequent finding in patients with both inherited and acquired diseases of heart muscle. In this review the mechanisms of energy generation in the healthy heart and their disturbances in heart muscle diseases are described. Therapeutic agents targeted at correcting cardiac energetic impairment are discussed.
心肌能量代谢受损在遗传性和获得性心肌疾病患者中很常见。本文综述了健康心脏中能量产生的机制及其在心肌疾病中的紊乱情况。并讨论了针对纠正心肌能量代谢受损的治疗药物。