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[基于针刺降压实验研究对基础研究与临床转化的思考]

[Our considerations about basic research and clinical translation based on experimental studies on acupuncture-induced blood-pressure reduction].

作者信息

Zhang Chao-nan, Huang Xue-kuan, Luo Yan, Jiang Juan, Wan Lei, Wang Ling

出版信息

Zhen Ci Yan Jiu. 2014 Oct;39(5):413-7, 426.

PMID:25518119
Abstract

Basic research is an important component of acupuncture medicine, and is also the driving force for improving clinical practice. Acupuncture therapy has been used to treat hypertension for many years in China, and its underlying mechanism has also been progressively and partially explored, but its therapeutic effect remains controversial. Authors of the present paper summarize the current state of experimental researches on acupuncture treatment of hypertension from the establishment of hypertension model, acupoint selection, stimulation parameters, and related action mechanisms, and simultaneously found a disassocia- tion between the basic research and clinical practice, particularly in the selection of acupoints and stimulation parameters. Therefore, to establish a bridge for better translation from many achievements of experimental studies to clinical application is of great practical significance. The authors hold that the existing problems of clinical practice should be the foothold of basic research, while successful transformation from basic research achievements to clinical practice is our ultimate target. Only in this way, can we incessantly achieve the goal of improving clinical therapeutic effect of acupuncture therapy from the phase of effectiveness verification, and promote the healthy development of acupuncturology.

摘要

基础研究是针灸医学的重要组成部分,也是提升临床实践的驱动力。在中国,针灸疗法用于治疗高血压已有多年,其潜在机制也已得到逐步且部分的探索,但其治疗效果仍存在争议。本文作者从高血压模型的建立、穴位选择、刺激参数及相关作用机制等方面总结了针灸治疗高血压的实验研究现状,同时发现基础研究与临床实践之间存在脱节,尤其是在穴位选择和刺激参数方面。因此,搭建一座桥梁,以便将众多实验研究成果更好地转化为临床应用具有重大现实意义。作者认为,临床实践中存在的问题应是基础研究的立足点,而将基础研究成果成功转化为临床实践是我们的最终目标。只有这样,我们才能在疗效验证阶段不断实现提高针灸疗法临床治疗效果的目标,并推动针灸学的健康发展。

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