Ioannoni B, Chalmers A H, Seow W K, McCormack J G, Thong Y H
Department of Child Health, University of Queensland, South Brisbane, Australia.
Int Arch Allergy Appl Immunol. 1989;89(4):349-54. doi: 10.1159/000234974.
Time-course and dose-dependent studies showed consistent suppression of phosphoinositide turnover in Con A-stimulated human lymphocytes in the presence of the plant alkaloid, tetrandrine. Significant inhibition of Con A-stimulated calcium flux was also observed. Furthermore, protein kinase C activity was also significantly inhibited by tetrandrine irrespective of whether Con A or phorbol myristate acetate was the stimulant. These results suggest that the immunosuppressive properties of tetrandrine are in part mediated by the capacity of tetrandrine to interfere with transmembrane signalling.
时间进程和剂量依赖性研究表明，在存在植物生物碱粉防己碱的情况下，粉防己碱对伴刀豆球蛋白A刺激的人淋巴细胞中的磷酸肌醇代谢具有持续的抑制作用。还观察到粉防己碱对伴刀豆球蛋白A刺激的钙通量有显著抑制作用。此外，无论刺激物是伴刀豆球蛋白A还是佛波醇肉豆蔻酸酯乙酸酯，粉防己碱都能显著抑制蛋白激酶C的活性。这些结果表明，粉防己碱的免疫抑制特性部分是由粉防己碱干扰跨膜信号传导的能力介导的。
