Niino Masaaki, Miyazaki Yusei, Fukazawa Toshiyuki, Kikuchi Seiji
Nihon Rinsho. 2014 Nov;72(11):1924-9.
Multiple sclerosis (MS) shows a multifold increase in prevalence with an increase in latitudes, both north and south of the equator. One of the potential factors related to the difference of the prevalence is vitamin D, because the strength of ambient ultraviolet light, which is essential for vitamin D production, decreases with increasing latitude. It is known that vitamin D has immunomodulatory functions and suppresses an animal model of MS. It is also considered that vitamin D-related genes are critical susceptible genes for MS. An approach from environmental and genetic aspects is needed to investigate the association between vitamin D and MS.
多发性硬化症（MS）的患病率随着纬度的增加而呈数倍增长，无论是在赤道以北还是以南。与患病率差异相关的潜在因素之一是维生素D，因为对维生素D生成至关重要的环境紫外线强度会随着纬度的增加而降低。已知维生素D具有免疫调节功能，并能抑制MS的动物模型。也有人认为与维生素D相关的基因是MS的关键易感基因。需要从环境和遗传方面进行研究，以探讨维生素D与MS之间的关联。
