Department of Neurology, University of Münster, Münster, Germany.
Department of Dermatology, University of Münster, Münster, Germany.
J Neuroimmunol. 2019 Apr 15;329:1-8. doi: 10.1016/j.jneuroim.2018.05.006. Epub 2018 May 18.
Multiple sclerosis (MS) is a disease of presumed auto-immune origin. Long-standing observations such as the correlation between MS incidence and geographical latitude or the levels of Vitamin D (Vit D) in the serum have implicated the environmental factors UVB radiation and diet in the etiology of the disease. Clinical trials have been conducted and are currently underway to elucidate whether a Vit D enriched diet or treatment with UVB can influence MS incidence, -severity, and -progression, as well as the ideal time point for treatment. This review summarizes the current scientific knowledge to the environmental factors UVB-light and Vit D concerning the clinical aspects of MS in epidemiological studies and clinical trials.
多发性硬化症（MS）是一种自身免疫性疾病。长期以来的观察结果表明，MS 的发病率与地理位置（即地理纬度）或血清中维生素 D（Vit D）水平之间存在相关性，这表明环境因素 UVB 辐射和饮食在疾病的病因学中起作用。已经进行了临床试验，并且目前正在进行临床试验，以阐明富含 Vit D 的饮食或 UVB 治疗是否可以影响 MS 的发病率、严重程度和进展，以及治疗的理想时间点。这篇综述总结了目前关于 MS 临床方面的流行病学研究和临床试验中有关 UVB 光和 Vit D 的环境因素的科学知识。
