Garcia Domenech R, Abril Mendez O, Galvez Alvarez J, Farga Marti A
School of Pharmacy, Department of Chemical Physics, University of Valencia, Spain.
Int J Rad Appl Instrum A. 1989;40(6):536-8. doi: 10.1016/0883-2889(89)90141-x.
This report studies the binding rate of the radiopharmaceuticals 99mTc-DTPA, 99mTc-EDTA and 99mTc-DMSA to plasmatic proteins. The proteins bind to the tested radiopharmaceuticals in the following sequence: 99mTc-DTPA less than 99mTc-DMSA(C1) less than 99mTc-EDTA less than 99mTc-DMSA(C2) where C1 and C2 represent two different Tc-DMSA complexes. The thermodynamic study suggests a quantitative relationship of radiopharmaceutical:protein = 1:1 and an almost nonexistent influence of the temperature, which means that the interacting forces in this process are relatively weak.
