Gatley S J
Franklin McLean Institute, Department of Radiology, University of Chicago, IL 60637.
Int J Rad Appl Instrum A. 1989;40(6):541-4. doi: 10.1016/0883-2889(89)90143-3.
A flow-through system is described for rapid purification of [18F]fluoride for nucleophilic substitution reactions. It depends on generation of [18F]fluorotrimethylsilane from aqueous 18F solutions and subsequent collection of the gas and its hydrolysis by base in near anhydrous acetonitrile. Potassium t-butoxide plus Kryptofix 2.2.2 was found to be a more effective base than K2CO3 plus Kryptofix or than tetraethylammonium hydroxide. The procedure takes 2-3 min and is thus faster than controlled removal of water from [18F]fluoride by evaporation. The trapped and hydrolyzed 18F was used in several nucleophilic substitution reactions. The flow-through system is also convenient for recovery of fluoride from impure and otherwise unreactive solutions, including residues from large scale 18F syntheses, and can thus lead to more efficient use of 18F where production of the radionuclide is limited.
本文描述了一种用于快速纯化[18F]氟化物以进行亲核取代反应的流通系统。它依赖于从含18F的水溶液中生成[18F]氟代三甲基硅烷，随后收集该气体并在近无水乙腈中通过碱进行水解。发现叔丁醇钾加穴醚2.2.2比碳酸钾加穴醚或氢氧化四乙铵是更有效的碱。该过程需要2 - 3分钟，因此比通过蒸发控制去除[18F]氟化物中的水更快。捕获并水解的18F用于多个亲核取代反应。该流通系统还便于从不纯的或其他无反应性的溶液中回收氟化物，包括大规模18F合成的残留物，因此在放射性核素产量有限的情况下可以更有效地利用18F。
