Żurawska-Płaksej Ewa, Ługowska Agnieszka, Hetmańczyk Katarzyna, Knapik-Kordecka Maria, Adamiec Rajmund, Piwowar Agnieszka
Department of Pharmaceutical Biochemistry, Wroclaw Medical University , Wroclaw , Poland .
Biomarkers. 2015 Feb;20(1):52-7. doi: 10.3109/1354750X.2014.992475. Epub 2014 Dec 18.
To investigate chitotriosidase (CHIT1) activity and chitinase-3-like protein 1 (YKL-40) concentration in plasma of type 2 diabetic patients and evaluate their relationship with kidney dysfunction.
94 diabetic subjects and 33 controls were enrolled in the study. Plasma CHIT1 activity and YKL-40 concentration were measured along with routine laboratory parameters.
Levels of CHIT1 and YKL-40 in plasma of type 2 diabetic patients increased progressively with the degree of albuminuria. CHIT1 discriminated normoalbuminuric subjects from those with abnormal albuminuria better than YKL-40.
CHIT1represent a supportive biomarker connected with development of diabetic vascular complications, especially kidney dysfunction.
研究2型糖尿病患者血浆中壳三糖苷酶（CHIT1）活性和几丁质酶-3样蛋白1（YKL-40）浓度，并评估它们与肾功能不全的关系。
94名糖尿病受试者和33名对照者纳入本研究。测量血浆CHIT1活性、YKL-40浓度以及常规实验室参数。
2型糖尿病患者血浆中CHIT1和YKL-40水平随蛋白尿程度逐渐升高。CHIT1区分正常白蛋白尿受试者和异常白蛋白尿受试者的能力优于YKL-40。
CHIT1是与糖尿病血管并发症尤其是肾功能不全发生相关的一种辅助生物标志物。
