Stahl S M, Lemoine P M, Ciaranello R D, Berger P A
Psychiatry Res. 1983 Nov;10(3):157-64. doi: 10.1016/0165-1781(83)90051-3.
We have investigated the functioning of alpha 2-adrenergic receptors in patients with major depressive disorder by measuring the specific binding of 3H-yohimbine, an alpha 2-adrenergic receptor antagonist, to platelet membranes. Bmax and Kd values for platelet 3H-yohimbine binding were normal in unmedicated patients with major depressive disorder, and did not correlate with scores on the Hamilton rating scale for depression. Platelet alpha 2-adrenergic antagonist sites were also unchanged in number or affinity in depressed patients after long-term treatment with a variety of antidepressant medications.
我们通过测量α2-肾上腺素能受体拮抗剂3H-育亨宾与血小板膜的特异性结合，研究了重度抑郁症患者中α2-肾上腺素能受体的功能。未服用药物的重度抑郁症患者血小板3H-育亨宾结合的Bmax和Kd值正常，且与汉密尔顿抑郁量表评分无关。在接受多种抗抑郁药物长期治疗的抑郁症患者中，血小板α2-肾上腺素能拮抗剂位点的数量或亲和力也未发生变化。
