Mendlewicz J, Hirsch D, Sevy S, Surmont D, Papadimitriou G, De Maertelaer V
Department of Psychiatry, Erasme Hospital, Free University of Brussels, Belgium.
Neuropsychobiology. 1989;22(2):61-7. doi: 10.1159/000118593.
The affinity (1/Kd) and density (Bmax) of alpha 2-adrenoreceptors in platelet membranes were studied in patients with major depressed illness (n = 10), affected first-degree relatives (n = 17), nonaffected first-degree relatives (n = 44) and controls (n = 31). The alpha 2 selective antagonist 3H-yohimbine was used as the radioligand. The mean Bmax values of affected subjects (probands and relatives) were significantly lower than those of controls. There was no difference in Kd values between the controls and affected subjects. There was a positive gradient of the mean Bmax values from the groups of probands to affected relatives, unaffected relatives and control subjects. A familial effect of Bmax values between members of the same families confirms a genetic control of alpha-receptor affinity. These results support the hypothesis that the density of alpha 2-adrenoreceptors, evaluated by 3H-yohimbine binding on human platelets, could be a potential vulnerability marker for affective disorder.
在患有重度抑郁症的患者（n = 10）、受影响的一级亲属（n = 17）、未受影响的一级亲属（n = 44）和对照组（n = 31）中，研究了血小板膜中α2 - 肾上腺素能受体的亲和力（1/Kd）和密度（Bmax）。使用α2选择性拮抗剂3H - 育亨宾作为放射性配体。受影响受试者（先证者和亲属）的平均Bmax值显著低于对照组。对照组和受影响受试者之间的Kd值没有差异。从先证者组到受影响亲属、未受影响亲属和对照受试者组，平均Bmax值呈正梯度变化。同一家族成员之间Bmax值的家族效应证实了α受体亲和力的遗传控制。这些结果支持这样的假设，即通过3H - 育亨宾与人血小板结合评估的α2 - 肾上腺素能受体密度可能是情感障碍的潜在易感性标志物。
