Olaru I D, Rachow A, Lange C, Ntinginya N E, Reither K, Hoelscher M, Vollrath O, Niemann S
<sup>*</sup>Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel Site, Borstel, Germany.
Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich, Munich, Germany; German Center for Infection Research Tuberculosis Unit, Munich, Germany.
Int J Tuberc Lung Dis. 2015 Jan;19(1):70-3. doi: 10.5588/ijtld.14.0403.
We evaluated the relationship between the degree of immunodeficiency indicated by the number of circulating CD4+ T-cells and Mycobacterium tuberculosis lineages identified by spoligotyping and mycobacterial interspersed repetitive units-variable number of tandem repeats genotyping in human immunodeficiency virus (HIV) infected individuals with pulmonary tuberculosis from Mbeya, Tanzania. Of M. tuberculosis strains from 129 patients, respectively 55 (42.6%) and 37 (28.7%) belonged to Latin American Mediterranean and Delhi/Central-Asian lineages, while 37 (28.7%) patients were infected with other strains. There was no difference in the distribution of M. tuberculosis lineages among patients with early or advanced stages of HIV infection (P = 0.785), indicating that the virulence of strains from these lineages may not be substantially different in vivo.
我们评估了坦桑尼亚姆贝亚地区感染人类免疫缺陷病毒（HIV）并患有肺结核的个体中，循环CD4 + T细胞数量所表明的免疫缺陷程度与通过间隔寡核苷酸分型法（spoligotyping）和分枝杆菌插入重复单位可变数目串联重复序列分型法（mycobacterial interspersed repetitive units-variable number of tandem repeats genotyping）鉴定的结核分枝杆菌谱系之间的关系。在129例患者的结核分枝杆菌菌株中，分别有55株（42.6%）和37株（28.7%）属于拉丁美洲地中海谱系和德里/中亚谱系，而37例（28.7%）患者感染的是其他菌株。HIV感染处于早期或晚期的患者中，结核分枝杆菌谱系的分布没有差异（P = 0.785），这表明这些谱系菌株在体内的毒力可能没有实质性差异。
