Malm Sven, Linguissi Laure S Ghoma, Tekwu Emmanuel M, Vouvoungui Jeannhey C, Kohl Thomas A, Beckert Patrick, Sidibe Anissa, Rüsch-Gerdes Sabine, Madzou-Laboum Igor K, Kwedi Sylvie, Penlap Beng Véronique, Frank Matthias, Ntoumi Francine, Niemann Stefan
Emerg Infect Dis. 2017 Mar;23(3):423-429. doi: 10.3201/eid2303.160679.
Tuberculosis is a leading cause of illness and death in Congo. No data are available about the population structure and transmission dynamics of the Mycobacterium tuberculosis complex strains prevalent in this central Africa country. On the basis of single-nucleotide polymorphisms detected by whole-genome sequencing, we phylogenetically characterized 74 MTBC isolates from Brazzaville, the capital of Congo. The diversity of the study population was high; most strains belonged to the Euro-American lineage, which split into Latin American Mediterranean, Uganda I, Uganda II, Haarlem, X type, and a new dominant sublineage named Congo type (n = 26). Thirty strains were grouped in 5 clusters (each within 12 single-nucleotide polymorphisms), from which 23 belonged to the Congo type. High cluster rates and low genomic diversity indicate recent emergence and transmission of the Congo type, a new Euro-American sublineage of MTBC.
结核病是刚果疾病和死亡的主要原因。关于这种中非国家流行的结核分枝杆菌复合群菌株的人群结构和传播动态，目前尚无数据。基于全基因组测序检测到的单核苷酸多态性，我们对来自刚果首都布拉柴维尔的74株结核分枝杆菌复合群分离株进行了系统发育特征分析。研究人群的多样性很高；大多数菌株属于欧美谱系，该谱系又分为拉丁美洲地中海型、乌干达I型、乌干达II型、哈勒姆型、X型，以及一个名为刚果型的新的优势亚谱系（n = 26）。30株菌株被分为5个簇（每个簇内有12个单核苷酸多态性），其中23株属于刚果型。高簇率和低基因组多样性表明刚果型是结核分枝杆菌复合群的一个新的欧美亚谱系，近期才出现并传播。
