肝细胞生长因子表明腹膜透析中的腹膜功能衰竭。

Hepatocyte growth factor signalizes peritoneal membrane failure in peritoneal dialysis.

作者信息

Bernardo Ana Paula, Oliveira José C, Santos Olívia, Carvalho Maria J, Cabrita António, Rodrigues Anabela

机构信息

Nephrology Department, St, António Hospital - Oporto Hospital Center, Oporto, Portugal.

出版信息

BMC Nephrol. 2014 Dec 17;15:201. doi: 10.1186/1471-2369-15-201.

DOI:10.1186/1471-2369-15-201

PMID:25519900

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4277824/

Abstract

BACKGROUND

Hepatocyte growth factor (HGF) counteracts peritoneal fibrosis in animal models and in-vitro studies, but no study explored effluent HGF in peritoneal dialysis (PD) patients with ultrafiltration failure (UFF). Our aim was to assess the relationship between effluent HGF with UF profile, free water transport (FWT) and small-solute transport.

METHODS

We performed 4-hour, 3.86% PET with additional UF measurement at 60 minutes in 68 PD patients. MTACcreatinine, FWT, small-pore ultrafiltration, and effluent HGF were quantified.

RESULTS

Effluent HGF negatively correlated with UF (r=-0.80, p=0.009) and FWT (r=-0.69, p=0.04). Patients with UFF had higher dialysate HGF (103 pg/mL vs 77 pg/mL, p=0.018) and, although not statistically significant, those with FWT compromise had also higher dialysate HGF compared with subgroup of UFF without FWT compromise (104 pg/mL vs 88 pg/mL, p=0.08). FWT≤45% without clinical UFF was documented in some patients who also had increased effluent HGF.

CONCLUSIONS

Dialysate HGF concentration is significantly higher among patients with UFF, specially, if FWT is impaired, being a sign of peritoneal membrane deterioration.

摘要

背景

在动物模型和体外研究中，肝细胞生长因子（HGF）可对抗腹膜纤维化，但尚无研究探讨超滤失败（UFF）的腹膜透析（PD）患者腹透液中的HGF。我们的目的是评估腹透液HGF与超滤情况、自由水转运（FWT）和小分子溶质转运之间的关系。

方法

我们对68例PD患者进行了4小时的3.86%腹膜平衡试验（PET），并在60分钟时额外测量超滤量。对肌酐清除率、FWT、小孔超滤和腹透液HGF进行了定量分析。

结果

腹透液HGF与超滤量（r = -0.80，p = 0.009）和FWT（r = -0.69，p = 0.04）呈负相关。UFF患者的腹透液HGF水平较高（103 pg/mL对77 pg/mL，p = 0.018），并且，尽管无统计学意义，但与无FWT受损的UFF亚组相比，FWT受损的患者腹透液HGF水平也较高（104 pg/mL对88 pg/mL，p = 0.08）。一些患者FWT≤45%且无临床UFF，但腹透液HGF也升高。