Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069 Dresden, Germany.
Chem Soc Rev. 2015 Jun 21;44(12):3968-96. doi: 10.1039/c4cs00339j.
In this review we highlight the potential for biomedical applications of dendritic glycopolymers based on polyamine scaffolds. The complex interplay of the molecular characteristics of the dendritic architectures and their specific interactions with various (bio)molecules are elucidated with various examples. A special role of the individual sugar units attached to the dendritic scaffolds and their density is identified, which govern ionic and H-bond interactions, and biological targeting, but to a large extent are also responsible for the significantly reduced toxicity of the dendritic glycopolymers compared to their polyamine scaffolds. Thus, the application of dendritic glycopolymers in drug delivery systems for gene transfection but also as therapeutics in neurodegenerative diseases has great promise.
在这篇综述中，我们强调了基于多胺支架的树枝状糖聚合物在生物医学应用方面的潜力。通过各种实例阐明了树枝状结构的分子特性与其与各种（生物）分子的特定相互作用之间的复杂相互作用。确定了连接到树枝状支架上的各个糖单元及其密度的特殊作用，这些作用控制着离子和氢键相互作用以及生物靶向性，但在很大程度上也导致树枝状糖聚合物的毒性比其多胺支架显著降低。因此，树枝状糖聚合物在基因转染的药物输送系统中的应用，以及在神经退行性疾病中的治疗应用都具有很大的前景。
