Isacco Laurie, Thivel David, Pereira Bruno, Duclos Martine, Boisseau Nathalie
Culture Sport Health Society Laboratory, EA 4660, and Exercise Performance, Health, Innovation Platform, Franche-Comte University, 25000, Besançon, France,
Eur J Appl Physiol. 2015 May;115(5):937-45. doi: 10.1007/s00421-014-3075-7. Epub 2014 Dec 18.
Synthetic ovarian hormones contained in oral contraceptives (OC) may alter the aerobic capacity and lipid metabolism in oral contraceptive users (OC+) compared with non-users (OC-). The aim of this study was thus to investigate the differences between OC- and OC+ (1) in cardiorespiratory parameters at the anaerobic threshold (AT) and at the maximal aerobic capacity and (2) in the exercise intensity (Lipoxmax) at which lipid oxidation rate is maximal (MLOR).
Twenty-one healthy untrained women (22.0 ± 0.6 years old) who took OC (OC+; low-dose monophasic OC, n = 11) or not (OC-; n = 10) performed two experimental exercise sessions. In the first one, cardiorespiratory parameters at the AT and at the maximal aerobic capacity were assessed during a maximal incremental exercise session. In the second one, Lipoxmax and MLOR were measured during a submaximal incremental exercise session.
No significant difference was observed in cardiorespiratory parameters at the AT and at the maximal aerobic capacity between OC+ and OC- women. OC+ women showed higher MLOR (7.6 ± 1.9 vs 4.6 ± 1.0 mg min(-1) kg FFM(-1); p < 0.01) that was elicited by higher Lipoxmax (45.2 ± 5.2 vs 36.2 ± 4.1 % of VO2max; p < 0.001) compared to OC- women.
OC+ and OC- women did not differ in cardiorespiratory parameters at the AT and at the maximal aerobic capacity. However, OC+ women show higher MLOR and Lipoxmax compared with OC- women. The hormonal status appears to be an important MLOR and Lipoxmax determinant in untrained women.
与未使用口服避孕药者（OC-）相比，口服避孕药（OC）中含有的合成卵巢激素可能会改变口服避孕药使用者（OC+）的有氧能力和脂质代谢。因此，本研究的目的是调查OC-和OC+之间在无氧阈（AT）和最大有氧能力时的心肺参数差异，以及在脂质氧化率最大时的运动强度（Lipoxmax）差异。
21名健康的未经训练的女性（22.0±0.6岁），其中服用OC者（OC+；低剂量单相OC，n = 11）或未服用者（OC-；n = 10）进行了两次实验性运动测试。在第一次测试中，在最大递增运动测试期间评估AT和最大有氧能力时的心肺参数。在第二次测试中，在次最大递增运动测试期间测量Lipoxmax和最大脂质氧化率（MLOR）。
OC+和OC-女性在AT和最大有氧能力时的心肺参数没有显著差异。与OC-女性相比，OC+女性的MLOR更高（7.6±1.9对4.6±1.0毫克·分钟-1·千克去脂体重-1；p<0.01），这是由更高的Lipoxmax引起的（45.2±5.2对36.2±4.1%的最大摄氧量；p<0.001）。
OC+和OC-女性在AT和最大有氧能力时的心肺参数没有差异。然而，与OC-女性相比，OC+女性的MLOR和Lipoxmax更高。激素状态似乎是未经训练女性MLOR和Lipoxmax的重要决定因素。
