Nissar Saniya, Sameer Aga Syed, Lone Tufail A, Chowdri Nissar A, Rasool Roohi
Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, INDIA E-mail :
Asian Pac J Cancer Prev. 2014;15(22):9621-5. doi: 10.7314/apjcp.2014.15.22.9621.
XRCC (X-ray cross-complementing group) genes contribute to important DNA repair mechanisms that play roles in the repair of single strand breaks (SSBs) induced by a variety of external and internal factors, including ionizing radiation, alkylating agents and reactive oxygen species. These repair genes have a pivotal role in maintaining genomic stability through different pathways of base excision repair (BER). The aim of this study was to investigate the XRCC3 Thr241Met gene polymorphism in colorectal cancer (CRC) in Kashmir. We investigated the genotype distribution of XRCC3 gene in 120 CRC cases in comparison with 150 healthy subjects and found a significant association between XRCC3 genotypes and CRC (p≤0.05). Both heterozygous genotype (Thr/Met) as well as homozygous variant genotype (Met/Met) were moderately associated with elevated risk of CRC [OR=2.53; OR=2.29 respectively]. Also, Thr/Met and Met/Met genotypes demonstrated a significant association with the risk of CRC (p=0.003). This study displayed a significantly elevated risk for CRC in individuals with XRCC3 Thr/Met and Met/Met Genotype of about 2.5 times that with the Thr/Thr wild genotype.
XRCC（X射线交叉互补组）基因有助于重要的DNA修复机制，这些机制在修复由多种外部和内部因素诱导的单链断裂（SSB）中发挥作用，这些因素包括电离辐射、烷基化剂和活性氧。这些修复基因在通过碱基切除修复（BER）的不同途径维持基因组稳定性方面具有关键作用。本研究的目的是调查克什米尔地区结直肠癌（CRC）中XRCC3 Thr241Met基因多态性。我们调查了120例CRC病例与150名健康对照者中XRCC3基因的基因型分布，发现XRCC3基因型与CRC之间存在显著关联（p≤0.05）。杂合基因型（Thr/Met）以及纯合变异基因型（Met/Met）均与CRC风险升高中度相关[分别为OR=2.53；OR=2.29]。此外，Thr/Met和Met/Met基因型与CRC风险存在显著关联（p=0.003）。本研究显示，具有XRCC3 Thr/Met和Met/Met基因型的个体患CRC的风险显著升高，约为具有Thr/Thr野生基因型个体的2.5倍。
