Manandhar Sajani, Shrestha Deepak Sundar, Taechaboonsermsk Pimsurang, Siri Sukhontha, Suparp Jarueyporn
Richa Bajimaya Memorial Foundation, Kathmandu, Nepal E-mail :
Asian Pac J Cancer Prev. 2014;15(22):9753-7. doi: 10.7314/apjcp.2014.15.22.9753.
To study the quality of life and to identify associated factors among breast cancer patients undergoing treatment in national cancer centers in Nepal.
One hundred breast cancer patients were selected and interviewed using a structured questionnaire. European Organization of Research and Treatment of Cancer EORTC-QLQ-C30 and EORTC-QLQ-BR23 were used to assess quality of life and modified Medical Outcome Study -Social Support survey(mMOS-SS) was used to assess social support. Only multi-item scales of EORTC C30 and BR23 were analyzed for relationships. Independent sample T-tests and ANOVA were applied to analyze differences in mean scores.
The score of global health status/quality of life (GHS/GQoL) was marginally above average (mean=52.8). The worst performed scales in C-30 were emotional and social function while best performed scales were physical and role function. In BR-23, most of the patients fell into the problematic group regarding sexual function and enjoyment. Almost 90% had financial difficulties. Symptom scales did not demonstrate many problems. Older individuals, patients with stage I breast cancer and thosewith good social support were found to have good GHS/GQoL. Of all the influencing factors, social support was established to have strong statistical associations with most of the functional scales: GHS/GQoL (0.003), emotional function (<0.001), cognitive function (0.020), social function (<0.001) and body image function (0.011). Body image was significantly associated with most of the influencing factors: monthly family income (0.003), type of treatment (<0.001), type of surgery (<0.001), stage of cancer (0.017) and social support (0.011).
Strategies to improve social support of the patients undergoing treatment should be given priority and financial difficulties faced by breast cancer patients should be well addressed from a policy making level by initiating health financing system.
研究尼泊尔国家癌症中心接受治疗的乳腺癌患者的生活质量，并确定相关因素。
选取100例乳腺癌患者，使用结构化问卷进行访谈。采用欧洲癌症研究与治疗组织（EORTC）的生活质量核心问卷（EORTC-QLQ-C30）和乳腺癌特异性问卷（EORTC-QLQ-BR23）评估生活质量，采用改良的医学结局研究社会支持调查（mMOS-SS）评估社会支持。仅分析EORTC C30和BR23的多项目量表之间的关系。应用独立样本T检验和方差分析来分析平均得分的差异。
总体健康状况/生活质量（GHS/GQoL）得分略高于平均水平（均值=52.8）。C-30中表现最差的量表是情感和社会功能，而表现最好的量表是身体和角色功能。在BR-23中，大多数患者在性功能和享受方面属于问题组。近90%的患者有经济困难。症状量表未显示出许多问题。发现年龄较大的个体、I期乳腺癌患者和社会支持良好的患者具有良好的GHS/GQoL。在所有影响因素中，社会支持与大多数功能量表具有很强的统计学关联：GHS/GQoL（0.003）、情感功能（<0.001）、认知功能（0.020）、社会功能（<0.001）和身体形象功能（0.011）。身体形象与大多数影响因素显著相关：家庭月收入（0.003）、治疗类型（<0.001）、手术类型（<0.001）、癌症分期（0.017）和社会支持（0.011）。
应优先采取策略改善接受治疗患者的社会支持，并且应从政策制定层面通过启动健康融资系统妥善解决乳腺癌患者面临的经济困难。
