Department of Surgery, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
Radiation Oncology Unit, King Abdulaziz University, Jeddah, Saudi Arabia.
PLoS One. 2019 Jul 10;14(7):e0219093. doi: 10.1371/journal.pone.0219093. eCollection 2019.
This cross-sectional study is aimed at assessing the quality of life in a cohort of breast cancer patients at the Oncology Department, King Abdulaziz University Hospital (KAUH), King Abdulaziz University (KAU), Jeddah, Saudi Arabia (SA), and to differentiate QoL among different groups. Mean time since diagnosis was 3.97±1.90 years. European Organization for Research and Treatment of Cancer Quality of Life Questionnaires-Core30 and BR23 (EORTC QLQ-C30 & BR23) were used to assess QoL in breast cancer survivors. ANOVA and independent t-test (parametric tests) were used for the categorical variables and Kruskal-Wallis and Mann-Whitney tests used for non-parametric tests. Linear regression analysis was done to measure predictors' significance and to calculate the coefficient of determination. Two hundred and eighty-four patients completed the survey. Global health status and functional scales, in most of the domains, were high, while symptom scales were moderate-to-low for most items, showing better QoL. Insomnia and fatigue were the most disturbing symptoms. Patients exhibited higher scores for body image and future perspective, while the least score is for sexual functioning. Global health, physical functioning, and role functioning were better in the age group ≤50 years (p<0.05). Premenopausal and perimenopausal patients showed a better level of functioning as compared to postmenopausal patients (p = 0.001). Premenopausal patients scored higher for sexual enjoyment, as compared to peri- and post-menopausal patients (p = 0.04). Systemic therapy side effects were more evident in the breast conservative surgery group. Predictors explained 8% of the variation in Physical functioning (R-squared = 0.08). A predictor that had a remarkable influence on physical functioning, as compared to the other predictors in the model, was menopausal status (P = 0.02). So, it was concluded that the breast cancer patients visiting our institute had a better quality of life regarding overall global health status as well as functional and symptom scales. Some issues, for instance, fatigue, insomnia, hair loss, and others, warrant good supportive therapy.
这项横断面研究旨在评估沙特阿拉伯吉达阿卜杜勒阿齐兹国王大学医院（KAUH）肿瘤学系的乳腺癌患者队列的生活质量，并对不同群体之间的生活质量进行区分。诊断后的平均时间为 3.97±1.90 年。使用欧洲癌症研究与治疗组织生活质量问卷核心 30 项（EORTC QLQ-C30）和 BR23（EORTC QLQ-C30 & BR23）评估乳腺癌幸存者的生活质量。对于分类变量使用方差分析和独立 t 检验（参数检验），对于非参数检验使用 Kruskal-Wallis 和 Mann-Whitney 检验。进行线性回归分析以测量预测因子的重要性并计算决定系数。284 名患者完成了调查。大多数领域的全球健康状况和功能量表较高，而大多数项目的症状量表为中低水平，表明生活质量较好。失眠和疲劳是最困扰的症状。患者表现出较高的身体形象和未来展望得分，而性功能得分最低。年龄≤50 岁的患者在全球健康、身体功能和角色功能方面表现更好（p<0.05）。与绝经后患者相比，绝经前和围绝经期患者的功能水平更好（p = 0.001）。与围绝经期和绝经后患者相比，绝经前患者的性享受评分更高（p = 0.04）。保乳手术组的全身治疗副作用更为明显。预测因子解释了身体功能变化的 8%（R-squared = 0.08）。与模型中的其他预测因子相比，绝经状态对身体功能有显著影响的预测因子（P = 0.02）。因此，我们得出的结论是，来我们研究所就诊的乳腺癌患者在整体全球健康状况以及功能和症状量表方面的生活质量更好。有些问题，例如疲劳、失眠、脱发等，需要良好的支持性治疗。
