膜联蛋白A2和CD105在胰腺导管腺癌中的表达与肿瘤复发及预后相关。
Annexin A2 and CD105 expression in pancreatic ductal adenocarcinoma is associated with tumor recurrence and prognosis.
作者信息
Huang Ya-Kai, Liu Hong, Wang Xin-Zheng, Zhu Shan
机构信息
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China E-mail :
出版信息
Asian Pac J Cancer Prev. 2014;15(22):9921-6. doi: 10.7314/apjcp.2014.15.22.9921.
To investigate the value of expression of annexin A2, microvessel density (MVD) and CD105 in pancreatic ductal adenocarcinoma (PDAC) tissues and adjacent normal tissues, immunohistochemical staining was used. The positive expression rate of Annexin A2 and the MVD in pancreatic ductal adenocarcinoma tissues was higher than that in in adjacent normal tissues (p<0.005). Expression of Annexin A2 and MVD correlated with histological grade (p<0.05). MVD of cancers in TNM stage IIb was higher than that in TNM stageI~IIa (p<0.026). Cancerous tissues with Annexin A2 staining grade 3+ had lower MVD than the tissues with the other Annexin A2 staining grade (p<0.05). Patients with high MVD had worse prognosis. However , our study did not confirm Annexin A2 was an independent risk factor for patients with PDAC. We confirmed MVD labeled by CD105 was an independent risk factor for patients with PDAC and had moderate predictive value of prognosis.
为研究膜联蛋白A2、微血管密度（MVD）及CD105在胰腺导管腺癌（PDAC）组织及癌旁正常组织中的表达情况，采用免疫组化染色法。胰腺导管腺癌组织中膜联蛋白A2的阳性表达率及MVD高于癌旁正常组织（p<0.005）。膜联蛋白A2表达及MVD与组织学分级相关（p<0.05）。TNM分期IIb期癌组织的MVD高于TNM分期I~IIa期（p<0.026）。膜联蛋白A2染色分级为3+的癌组织MVD低于其他膜联蛋白A2染色分级的组织（p<0.05）。MVD高的患者预后较差。然而，我们的研究未证实膜联蛋白A2是胰腺导管腺癌患者的独立危险因素。我们证实CD105标记的MVD是胰腺导管腺癌患者的独立危险因素，对预后有中度预测价值。
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