Vriz Olga, Zito Concetta, di Bello Vitantonio, La Carrubba Salvatore, Driussi Caterina, Carerj Scipione, Bossone Eduardo, Antonini-Canterin Francesco
Cardiology and Emergency Department, Sant'Antonio Hospital, Via Trento-Trieste 33, San Daniele del Friuli, 33038, Udine, Italy.
Institute of Cardiology, University of Messina, Messina, Italy.
Heart Vessels. 2016 Mar;31(3):360-9. doi: 10.1007/s00380-014-0600-x. Epub 2014 Dec 18.
The analysis of wave intensity (WI) evaluates the working condition of the heart interacting with the arterial system. WI in normal subjects has two peaks, the first (W 1) reflects left ventricle (LV) contractile performance, the second (W 2) is related to the ability of the LV to actively stop aortic blood flow. The aim of the study was to investigate the reference values of W 1 and W 2 in a group of apparently healthy subjects through a radiofrequency-based system. 680 subjects (388 men mean age 43.0 ± 17.4 years, range 16-92; 292 women mean age 44.8 ± 17.7 years, range 16-86) were enrolled and underwent physical examination, blood pressure (BP) and heart rate (HR) measurements and comprehensive transthoracic echocardiogram was performed. Measurement of local WI was obtained at the level of the left common carotid artery before the bifurcation, using a high definition echo-tracking system. W 1 was (12.37 ± 6.89) × 10(3) and (9.76 ± 4.8) × 10(3) mmHg m/s(3), p < 0.0001; W 2 was (3.21 ± 1.81) × 10(3) and (2.98 ± 1.69) × 10(3) mmHg m/s(3), p = ns in men and women, respectively. The cohort was divided into 5 age groups (ages 16-29; 30-39; 40-49; 50-59; >60) and stratified by gender. After adjustment for height, systolic BP and HR, W 1 decreased with age (p < 0.0001 in men and p = 0.026 in women for trend) while no relation was found for W 2. Multivariable regression analysis using age, gender, height, systolic BP, HR, ejection fraction and stroke volume indexed by body surface are predicted W 1 and age, systolic BP, HR and E/A as a measure of diastolic function, predicted W 2. Inter and intra-observer variability and feasibility of WI analysis were satisfactory. We reported the values and their clinical correlations of the two peaks (W 1 and W 2) of WI, a non-invasive hemodynamic index for assessing ventricular-arterial coupling in a large group of apparently healthy subjects.
波强度（WI）分析用于评估心脏与动脉系统相互作用的工作状态。正常受试者的WI有两个峰值，第一个（W1）反映左心室（LV）的收缩功能，第二个（W2）与LV主动停止主动脉血流的能力有关。本研究的目的是通过基于射频的系统调查一组表面健康受试者的W1和W2参考值。纳入680名受试者（388名男性，平均年龄43.0±17.4岁，范围16 - 92岁；292名女性，平均年龄44.8±17.7岁，范围16 - 86岁），进行体格检查、测量血压（BP）和心率（HR），并进行全面的经胸超声心动图检查。使用高分辨率回声跟踪系统在左颈总动脉分叉前水平测量局部WI。男性的W1为（12.37±6.89）×10³和（9.76±4.8）×10³mmHg m/s³，p<0.0001；女性的W2为（3.21±1.81）×10³和（2.98±1.69）×10³mmHg m/s³，p =无统计学意义。该队列分为5个年龄组（16 - 29岁；30 - 39岁；40 - 49岁；50 - 59岁；>60岁）并按性别分层。在调整身高、收缩压和心率后，W1随年龄下降（男性趋势p<0.0001，女性p = 0.026），而未发现W2与年龄有关。使用年龄、性别、身高、收缩压、心率、射血分数和体表面积指数化的每搏量进行多变量回归分析预测W1，使用年龄、收缩压、心率和E/A作为舒张功能指标预测W2。观察者间和观察者内的变异性以及WI分析的可行性均令人满意。我们报告了WI的两个峰值（W1和W2）的值及其临床相关性，WI是一种用于评估一大组表面健康受试者心室 - 动脉耦合的非侵入性血流动力学指标。
