从中胚层诱导多能干细胞分化而来的中胚层。

Mesoderm Differentiation from hiPS Cells.

作者信息

Miwa Hiroyuki, Era Takumi

机构信息

Kumamoto University, 2-39-1 Kurokami, Chuo-Ku, Kumamoto, 860-8555, Japan.

出版信息

Methods Mol Biol. 2016;1357:403-13. doi: 10.1007/7651_2014_162.

DOI:10.1007/7651_2014_162

PMID:25520286

Abstract

Human induced pluripotent stem (hiPS) cells are very attractive tools for modeling diseases and regenerative medicine. However, to achieve them, the efficient differentiation methods of hiPS cells into aimed cell type in vitro are necessary. Because mesoderm cells are useful in particular, we have developed the differentiation of mouse embryonic stem (mES) cells into mesoderm cells previously. In this time, these methods were improved for hiPS cells and now human mesoderm cells are able to be obtained efficiently. It is certain that the new methods are applicable to various studies and therapies.

摘要

人诱导多能干细胞（hiPS细胞）是用于疾病建模和再生医学的极具吸引力的工具。然而，要实现这一点，需要高效的体外将hiPS细胞分化为目标细胞类型的方法。由于中胚层细胞特别有用，我们之前已经开发了将小鼠胚胎干细胞（mES细胞）分化为中胚层细胞的方法。此次，这些方法针对hiPS细胞进行了改进，现在能够高效获得人源中胚层细胞。可以确定的是，这些新方法适用于各种研究和治疗。