Boratto Paulo, Albarnaz Jonas Dutra, Almeida Gabriel Magno de Freitas, Botelho Lucas, Fontes Alide Caroline Lima, Costa Adriana Oliveira, Santos Daniel de Assis, Bonjardim Cláudio Antônio, La Scola Bernard, Kroon Erna Geessien, Abrahão Jônatas Santos
Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, Laboratório de Vírus, Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, Laboratório de Micologia, Belo Horizonte, MG, Brazil.
J Virol. 2015 Mar;89(5):2962-5. doi: 10.1128/JVI.03177-14. Epub 2014 Dec 17.
Acanthamoeba is a genus of free-living amoebas distributed worldwide. Few studies have explored the interactions between these protozoa and their infecting giant virus, Acanthamoeba polyphaga mimivirus (APMV). Here we show that, once the amoebal encystment is triggered, trophozoites become significantly resistant to APMV. Otherwise, upon infection, APMV is able to interfere with the expression of a serine proteinase related to amoebal encystment and the encystment can no longer be triggered.
棘阿米巴是一种自由生活的阿米巴原虫属，分布于世界各地。很少有研究探讨这些原生动物与其感染的巨型病毒——多噬棘阿米巴米米病毒（APMV）之间的相互作用。在这里，我们表明，一旦触发阿米巴包囊形成，滋养体对APMV就会产生显著抗性。否则，在感染时，APMV能够干扰与阿米巴包囊形成相关的丝氨酸蛋白酶的表达，从而无法再触发包囊形成。
