富含亮氨酸胶质瘤失活蛋白 1 抗体脑炎：一例报告。
Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report.
机构信息
Departments of Neurology (Y.M., N.G.) and Radiology (D.T.), University of Massachusetts Medical School, Worcester, MA.
出版信息
Neurol Neuroimmunol Neuroinflamm. 2014 Dec 11;1(4):e51. doi: 10.1212/NXI.0000000000000051. eCollection 2014 Dec.
OBJECTIVE
To describe a case of leucine-rich glioma-inactivated protein 1 (LGI1) antibody-associated encephalitis.
METHODS
The clinical and ancillary data and brain MRIs were gathered retrospectively by chart review. Relevant literature on similar cases was also reviewed.
RESULTS
The diagnosis of LGI1 antibody-associated autoimmune encephalitis was based on the typical clinical presentation of seizures, psychiatric symptoms, and memory loss as well as negative diagnostic testing for cancer; the diagnosis was confirmed by positive LGI1 antibody. The patient responded favorably to treatment with IV immunoglobulin and continues to do well.
CONCLUSION
LGI1 antibody-associated encephalitis has increasingly been recognized as a primary autoimmune disorder with good prognosis and response to treatment.
目的
描述一例亮氨酸丰富的胶质瘤失活蛋白 1（LGI1）抗体相关脑炎病例。
方法
通过病历回顾收集临床和辅助数据及脑部 MRI。还回顾了类似病例的相关文献。
结果
LGI1 抗体相关自身免疫性脑炎的诊断基于癫痫发作、精神症状和记忆力减退的典型临床表现，以及癌症诊断检测呈阴性；该诊断通过 LGI1 抗体阳性得到确认。该患者对静脉注射免疫球蛋白治疗反应良好，病情持续好转。
结论
LGI1 抗体相关脑炎已逐渐被认为是一种具有良好预后和治疗反应的原发性自身免疫性疾病。
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