Piaru Suthagar Pillai, Mahmud Roziahanim, Abdul Majid Amin Malik Shah, Ismail Sabariah, Man Che Nin
J Sci Food Agric. 2012 Feb;92(3):593-7. doi: 10.1002/jsfa.4613.
In this study the chemical composition, antioxidant activities and cytotoxic effect of the essential oils of Myristica fragrans (nutmeg) and Morinda citrifolia (mengkudu) were determined.
Thirty-eight compounds in nutmeg oil and six compounds in mengkudu oil were identified by gas chromatography–mass spectrometry. The free radical scavenging activity of nutmeg oil was superior of that mengkudu oil. The MTT assay of nutmeg oil on human colorectal carcinoma (HCT-116) and human breast carcinoma (MCF-7) cell lines showed IC₅₀ values of 78.61 and 66.45 µg mL⁻¹, respectively. The mengkudu oil exhibited IC₅₀ values of 91.46 and 78.15 µg mL⁻¹ for HCT-116 and MCF-7, respectively.
The results showed that nutmeg oil can be developed as potent anti-cancer and antioxidant drugs.
本研究测定了肉豆蔻和巴戟天精油的化学成分、抗氧化活性及细胞毒性作用。
采用气相色谱-质谱联用仪鉴定出肉豆蔻油中的38种化合物和巴戟天油中的6种化合物。肉豆蔻油的自由基清除活性优于巴戟天油。肉豆蔻油对人结肠癌细胞系（HCT-116）和人乳腺癌细胞系（MCF-7）的MTT试验显示IC₅₀值分别为78.61和66.45 μg mL⁻¹。巴戟天油对HCT-116和MCF-7的IC₅₀值分别为91.46和78.15 μg mL⁻¹。
结果表明，肉豆蔻油可开发成为有效的抗癌和抗氧化药物。
