Wu Chih-Feng, Wu Chieh-Shan, Yu Wei-Wen, Huang Ming-Yii
Division of Surgical Oncology, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Department of Surgery, Faculty of Medicine, College of Medicine, , Kaohsiung Medical University, Kaohsiung, Taiwan.
Head Neck. 2015 Oct;37(10):E134-8. doi: 10.1002/hed.23941. Epub 2015 Jun 22.
Primary oral mucosal melanoma is uncommon. However, it is an aggressive entity, and the absence of a standardized treatment protocol makes for an extremely poor prognosis.
We described the clinical course and treatment by arterial chemotherapy of an 87-year-old patient with nonresectable huge buccal malignant melanoma. Continuous intra-arterial infusion of fluorouracil (50 mg/24 hours) and 1 intermittent weekly 10-mg shot of cisplatin were given.
The patient with oral melanoma presented with a roughly 6- × 4-cm exophytic mass that was noticed on the right buccal mucosa. The buccal tumor regressed dramatically until complete disappearance of the tumor mass was achieved at 2.5 months after intra-arterial chemotherapy was initiated. In total, 2880 mg of fluorouracil and 80 mg of cisplatin were administrated. The side effects of intra-arterial chemotherapy were mild and tolerable.
Our data demonstrate that intra-arterial chemotherapy could be an alternative treatment for nonresectable buccal malignant melanoma.
原发性口腔黏膜黑色素瘤并不常见。然而，它是一种侵袭性疾病，且缺乏标准化治疗方案导致预后极差。
我们描述了一名87岁不可切除的巨大颊部恶性黑色素瘤患者的临床病程及动脉化疗治疗情况。持续动脉内输注氟尿嘧啶（50毫克/24小时），并每周间歇性注射1次10毫克顺铂。
该口腔黑色素瘤患者右侧颊黏膜出现一个约6×4厘米的外生性肿物。动脉化疗开始后2.5个月，颊部肿瘤显著消退直至肿瘤块完全消失。总共给予了2880毫克氟尿嘧啶和80毫克顺铂。动脉化疗的副作用轻微且可耐受。
我们的数据表明，动脉化疗可能是非可切除颊部恶性黑色素瘤的一种替代治疗方法。
