Kovács A F, Grüterich G, Wagner M
Clinic of Maxillofacial Plastic Surgery, Johann Wolfgang Goethe-University Medical School, Frankfurt am Main, Germany.
J Chemother. 2002 Feb;14(1):95-101. doi: 10.1179/joc.2002.14.1.95.
The impact of intra-arterial local chemotherapy on squamous cell carcinomas of the oral cavity is doubtful when considering long-term survival, especially in cases of nodal involvement. But even in patients with strictly local disease it is not possible to determine the effect of intra-arterial chemotherapy because it is mainly used as a neoadjuvant treatment modality. In the present paper, long-term courses of two patients are described who refused any further treatment after one cycle of intra-arterial chemotherapy with cisplatin followed by systemic chemotherapy with 5-fluorouracil and one cycle of intra-arterial chemotherapy with high-dose cisplatin, respectively. The aim of the paper is to demonstrate the potential of local chemotherapy in responders. The impact of this treatment modality in incurable patients is discussed, too. This may offer a point in favor of use of intra-arterial chemotherapy in combination treatment regimens.
考虑到长期生存率，尤其是在有淋巴结受累的情况下，动脉内局部化疗对口腔鳞状细胞癌的影响存疑。但即使是患有严格意义上的局部疾病的患者，也无法确定动脉内化疗的效果，因为它主要用作新辅助治疗方式。在本文中，描述了两名患者的长期病程，他们在分别接受了一个周期的顺铂动脉内化疗，随后进行5-氟尿嘧啶全身化疗，以及一个周期的高剂量顺铂动脉内化疗后，拒绝了任何进一步治疗。本文的目的是证明局部化疗对有反应者的潜力。还讨论了这种治疗方式对无法治愈的患者的影响。这可能为在联合治疗方案中使用动脉内化疗提供一个有利点。
