Whitsett Jeffrey A, Alenghat Theresa
Perinatal Institute, Division of Neonatology, Division of Perinatal Biology and Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Division of Immunobiology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Nat Immunol. 2015 Jan;16(1):27-35. doi: 10.1038/ni.3045.
The epithelial surfaces of the lungs are in direct contact with the environment and are subjected to dynamic physical forces as airway tubes and alveoli are stretched and compressed during ventilation. Mucociliary clearance in conducting airways, reduction of surface tension in the alveoli, and maintenance of near sterility have been accommodated by the evolution of a multi-tiered innate host-defense system. The biophysical nature of pulmonary host defenses are integrated with the ability of respiratory epithelial cells to respond to and 'instruct' the professional immune system to protect the lungs from infection and injury.
肺的上皮表面与外界环境直接接触，在通气过程中，气道和肺泡会被拉伸和压缩，从而受到动态物理力的作用。多层先天性宿主防御系统的进化，使得传导气道中的黏液纤毛清除功能、肺泡表面张力的降低以及近乎无菌状态得以维持。肺部宿主防御的生物物理特性与呼吸道上皮细胞响应并“指导”专业免疫系统以保护肺部免受感染和损伤的能力相结合。
