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How malaria parasites avoid running out of ammo.

作者信息

Arnot David E

机构信息

University of Edinburgh, School of Biological Sciences, Institute for Immunology and Infection Research, Edinburgh, United Kingdom.

出版信息

PLoS Genet. 2014 Dec 18;10(12):e1004878. doi: 10.1371/journal.pgen.1004878. eCollection 2014 Dec.

DOI:10.1371/journal.pgen.1004878
PMID:25522011
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4270491/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d8a/4270491/0759ee682eb8/pgen.1004878.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d8a/4270491/0759ee682eb8/pgen.1004878.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d8a/4270491/0759ee682eb8/pgen.1004878.g001.jpg

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本文引用的文献

1
Generation of antigenic diversity in Plasmodium falciparum by structured rearrangement of Var genes during mitosis.恶性疟原虫在有丝分裂期间通过Var基因的结构化重排产生抗原多样性。
PLoS Genet. 2014 Dec 18;10(12):e1004812. doi: 10.1371/journal.pgen.1004812. eCollection 2014 Dec.
2
DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families.DNA 二级结构与主要恶性疟原虫可变表面抗原基因家族的重组有关。
Nucleic Acids Res. 2014 Feb;42(4):2270-81. doi: 10.1093/nar/gkt1174. Epub 2013 Nov 18.
3
Severe malaria is associated with parasite binding to endothelial protein C receptor.
严重疟疾与寄生虫结合内皮蛋白 C 受体有关。
Nature. 2013 Jun 27;498(7455):502-5. doi: 10.1038/nature12216. Epub 2013 Jun 5.
4
Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families.恶性疟原虫有丝分裂进化显示稳定的核心基因组，但抗原家族存在重组。
PLoS Genet. 2013;9(2):e1003293. doi: 10.1371/journal.pgen.1003293. Epub 2013 Feb 7.
5
The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains.VAR2CSA 蛋白的硫酸软骨素 A 结合位点涉及多个 N 端结构域。
J Biol Chem. 2011 May 6;286(18):15908-17. doi: 10.1074/jbc.M110.191510. Epub 2011 Mar 11.
6
Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes--divide and conquer.恶性疟原虫红细胞膜蛋白 1 的多样性——分而治之。
PLoS Comput Biol. 2010 Sep 16;6(9):e1000933. doi: 10.1371/journal.pcbi.1000933.
7
The progression of the intra-erythrocytic cell cycle of Plasmodium falciparum and the role of the centriolar plaques in asynchronous mitotic division during schizogony.恶性疟原虫红细胞内细胞周期的进展和中心粒斑在裂殖生殖过程中无丝分裂的异步分裂中的作用。
Int J Parasitol. 2011 Jan;41(1):71-80. doi: 10.1016/j.ijpara.2010.07.012. Epub 2010 Sep 17.
8
Ectopic recombination of a malaria var gene during mitosis associated with an altered var switch rate.疟疾var基因在有丝分裂期间的异位重组与var转换率改变有关。
J Mol Biol. 2009 Jun 12;389(3):453-69. doi: 10.1016/j.jmb.2009.04.032. Epub 2009 Apr 21.
9
Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that mosaic gene expression is prominent in antigenic variation and is favored by archive substructure.对布氏锥虫VSG基因沉默文库的分析表明，嵌合基因表达在抗原变异中很突出，并且受到文库亚结构的青睐。
Genome Res. 2007 Sep;17(9):1344-52. doi: 10.1101/gr.6421207. Epub 2007 Jul 25.
10
Variable var transition rates underlie antigenic variation in malaria.可变的转变率是疟疾抗原变异的基础。
Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):11129-34. doi: 10.1073/pnas.0402347101. Epub 2004 Jul 15.