疟原虫如何避免耗尽“弹药”。 - Suppr

How malaria parasites avoid running out of ammo.

作者信息

Arnot David E

机构信息

University of Edinburgh, School of Biological Sciences, Institute for Immunology and Infection Research, Edinburgh, United Kingdom.

出版信息

PLoS Genet. 2014 Dec 18;10(12):e1004878. doi: 10.1371/journal.pgen.1004878. eCollection 2014 Dec.

DOI:10.1371/journal.pgen.1004878

PMID:25522011

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4270491/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d8a/4270491/0759ee682eb8/pgen.1004878.g001.jpg

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How malaria parasites avoid running out of ammo.

作者信息

Arnot David E

机构信息

University of Edinburgh, School of Biological Sciences, Institute for Immunology and Infection Research, Edinburgh, United Kingdom.

出版信息

PLoS Genet. 2014 Dec 18;10(12):e1004878. doi: 10.1371/journal.pgen.1004878. eCollection 2014 Dec.

DOI:10.1371/journal.pgen.1004878

PMID:25522011

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4270491/

Abstract

摘要

相似文献

How malaria parasites avoid running out of ammo.

PLoS Genet. 2014 Dec 18;10(12):e1004878. doi: 10.1371/journal.pgen.1004878. eCollection 2014 Dec.

The varieties of gene amplification, diversification and hypervariability in the human malaria parasite, Plasmodium falciparum.

Mol Biochem Parasitol. 2009 Aug;166(2):109-16. doi: 10.1016/j.molbiopara.2009.04.003. Epub 2009 Apr 16.

Antigenic Variation in Plasmodium falciparum.

Results Probl Cell Differ. 2015;57:47-90. doi: 10.1007/978-3-319-20819-0_3.

Malaria strains appear to gang up against immune defenses.

Science. 1998 Feb 20;279(5354):1136. doi: 10.1126/science.279.5354.1136.

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Curr Opin Microbiol. 2005 Aug;8(4):428-33. doi: 10.1016/j.mib.2005.06.011.

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Science. 1995 Aug 11;269(5225):755. doi: 10.1126/science.7638584.

Malaria vaccines based on the Plasmodium falciparum merozoite surface protein 3--should we avoid amino acid sequence polymorphisms or embrace them?

J Infect Dis. 2007 Jan 15;195(2):171-3. doi: 10.1086/509813. Epub 2006 Dec 13.

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Science. 2002 Jul 19;297(5580):345-7. doi: 10.1126/science.1074484.

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Curr Opin Microbiol. 2005 Aug;8(4):434-40. doi: 10.1016/j.mib.2005.06.007.

引用本文的文献

Advances in genetics and genomics: use and limitations in achieving malaria elimination goals.

Pathog Glob Health. 2015 May;109(3):123-41. doi: 10.1179/2047773215Y.0000000015.

本文引用的文献

Generation of antigenic diversity in Plasmodium falciparum by structured rearrangement of Var genes during mitosis.

PLoS Genet. 2014 Dec 18;10(12):e1004812. doi: 10.1371/journal.pgen.1004812. eCollection 2014 Dec.

DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families.

Nucleic Acids Res. 2014 Feb;42(4):2270-81. doi: 10.1093/nar/gkt1174. Epub 2013 Nov 18.

Severe malaria is associated with parasite binding to endothelial protein C receptor.

Nature. 2013 Jun 27;498(7455):502-5. doi: 10.1038/nature12216. Epub 2013 Jun 5.

Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families.

PLoS Genet. 2013;9(2):e1003293. doi: 10.1371/journal.pgen.1003293. Epub 2013 Feb 7.

The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains.

J Biol Chem. 2011 May 6;286(18):15908-17. doi: 10.1074/jbc.M110.191510. Epub 2011 Mar 11.

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PLoS Comput Biol. 2010 Sep 16;6(9):e1000933. doi: 10.1371/journal.pcbi.1000933.

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Int J Parasitol. 2011 Jan;41(1):71-80. doi: 10.1016/j.ijpara.2010.07.012. Epub 2010 Sep 17.

Ectopic recombination of a malaria var gene during mitosis associated with an altered var switch rate.

J Mol Biol. 2009 Jun 12;389(3):453-69. doi: 10.1016/j.jmb.2009.04.032. Epub 2009 Apr 21.

Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that mosaic gene expression is prominent in antigenic variation and is favored by archive substructure.

Genome Res. 2007 Sep;17(9):1344-52. doi: 10.1101/gr.6421207. Epub 2007 Jul 25.

Variable var transition rates underlie antigenic variation in malaria.

Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):11129-34. doi: 10.1073/pnas.0402347101. Epub 2004 Jul 15.

How malaria parasites avoid running out of ammo.

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How malaria parasites avoid running out of ammo.

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