Gunawardena Sharmini, Karunaweera Nadira D
Pathog Glob Health. 2015 May;109(3):123-41. doi: 10.1179/2047773215Y.0000000015.
Success of the global research agenda towards eradication of malaria will depend on the development of new tools, including drugs, vaccines, insecticides and diagnostics. Genetic and genomic information now available for the malaria parasites, their mosquito vectors and human host, can be harnessed to both develop these tools and monitor their effectiveness. Here we review and provide specific examples of current technological advances and how these genetic and genomic tools have increased our knowledge of host, parasite and vector biology in relation to malaria elimination and in turn enhanced the potential to reach that goal. We then discuss limitations of these tools and future prospects for the successful achievement of global malaria elimination goals.
全球疟疾根除研究议程的成功将取决于新工具的开发，包括药物、疫苗、杀虫剂和诊断方法。目前可获取的疟原虫、其蚊媒和人类宿主的遗传和基因组信息，可用于开发这些工具并监测其有效性。在此，我们回顾并提供当前技术进展的具体实例，以及这些遗传和基因组工具如何增进了我们对与疟疾消除相关的宿主、寄生虫和媒介生物学的了解，进而增强了实现该目标的潜力。然后，我们讨论这些工具的局限性以及成功实现全球疟疾消除目标的未来前景。
