Suzuki K, Reshad K, Akiyama J, Itoi K, Hirata T, Muro K
Nihon Kyobu Shikkan Gakkai Zasshi. 1989 Jun;27(6):703-11.
The serum level of tissue polypeptide antigen (TPA) has been measured by a new immunoradiometric assay (IRMA) method that has been recently developed using a specific antibody, and compared with the results obtained by the conventional double antibody method, using a polyclonal antibody. Both methods gave essentially the same results, i.e. the serum TPA level in patients with primary lung cancer was higher when compared with non-malignant pulmonary diseases and healthy individuals (p less than 0.01). However the positive rate and average values of TPA with patients of non-malignant diseases were found to be lower by the new IRMA method than by the conventional method. This may be due to the improvement in specificity and accuracy of this newer method of assay, as they also statistically decrease within the cut off level (110 U/L) estimated in non-malignant diseases and healthy individuals. Therefore, it has been concluded that the IRMA method is more suitable than the conventional method for diagnosis of primary lung cancer.
采用最近研发的使用特异性抗体的新型免疫放射分析（IRMA）方法测定了组织多肽抗原（TPA）的血清水平，并与使用多克隆抗体的传统双抗体法所获结果进行了比较。两种方法得出的结果基本相同，即与非恶性肺部疾病患者和健康个体相比，原发性肺癌患者的血清TPA水平更高（p<0.01）。然而，发现新型IRMA法测定非恶性疾病患者的TPA阳性率和平均值低于传统方法。这可能是由于这种更新的检测方法在特异性和准确性方面有所提高，因为在非恶性疾病患者和健康个体中估计的临界值水平（110 U/L）内，其数值在统计学上也有所降低。因此，得出结论，IRMA法比传统方法更适合用于原发性肺癌的诊断。
