Mino N, Iio A, Ata M, Hamamoto K
Dept. of Radiology, Ehime Univ. School of Med.
Gan No Rinsho. 1988 Mar;34(3):321-5.
The serum level of the squamous cell carcinoma-related antigen (SCC-Ag) has been measured by a new immunoradiometric assay (IRMA) method that has been recently developed by using a monoclonal antibody, and compared with the results obtained by the conventional double-antibody method using a polyclonal antibody. Both methods gave essentially the same results, that the serum SCC-Ag level was high in patients with squamous cell carcinoma of various organs when compared with other types of lung cancer or benign diseases. However, the percentages of the serum SCC-Ag level over the normal range were found to be higher by the new IRMA method than by the conventional method. This may be due to the improvement in sensitivity and accuracy of this newer method of assay, which also results in a considerable decrease in the normal range estimated in healthy subjects. Therefore, it has been concluded that this new method is more suitable than the conventional method for an early diagnosis of squamous cell carcinoma in all organs.
采用一种最近利用单克隆抗体开发的新型免疫放射分析（IRMA）方法测定了血清鳞状细胞癌相关抗原（SCC-Ag）水平，并与使用多克隆抗体的传统双抗体方法所获结果进行了比较。两种方法所得结果基本相同，即与其他类型肺癌或良性疾病相比，各种器官鳞状细胞癌患者的血清SCC-Ag水平较高。然而，发现新型IRMA方法检测出血清SCC-Ag水平超出正常范围的百分比高于传统方法。这可能是由于这种更新的检测方法在灵敏度和准确性方面有所提高，这也导致健康受试者估计的正常范围大幅降低。因此，得出结论，这种新方法比传统方法更适合于所有器官鳞状细胞癌的早期诊断。
