头颈部癌症患者中幽门螺杆菌的检测：一项结合血清学、聚合酶链反应和快速尿素酶试验的前瞻性对比研究结果
Detection of Helicobacter pylori in patients with head and neck cancer: Results from a prospective comparative study combining serology, polymerase chain reaction, and rapid urease test.
作者信息
Morand Grégoire B, Fellmann Jonas, Laske Roman D, Weisert Jan U, Soltermann Alex, Zbinden Reinhard, Probst Rudolf, Huber Gerhard F
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Switzerland.
Institute of Surgical Pathology, University Hospital Zurich, Switzerland.
出版信息
Head Neck. 2016 May;38(5):769-74. doi: 10.1002/hed.23958. Epub 2015 Jun 20.
BACKGROUND
The purpose of this study was to evaluate prospectively the presence and impact of the gastric carcinogen Helicobacter pylori (H. pylori) in the upper aerodigestive tract. Previous studies suggested it could represent a risk factor for head and neck squamous cell carcinoma (HNSCC).
METHODS
Serology, rapid urease test, and quantitative polymerase chain reaction (qPCR) for H. pylori were performed in patients with head and neck cancer (N = 56) and cancer-free controls (N = 90). Comparison between groups was done using logistic regression analysis.
RESULTS
Rates of positive serology and rapid urease test did not differ between the 2 groups in logistic regression analysis (p = .677 and p = .633, respectively). Birth in a developing country and age above 50 years old were predictors of positive serology (p < .001 and p = .040, respectively). Using qPCR, no biopsy showed the presence of H. pylori.
CONCLUSION
This study challenges the concept that H. pylori may be a risk factor for HNSCC.
背景
本研究的目的是前瞻性评估胃致癌物幽门螺杆菌（H. pylori）在上呼吸道消化道中的存在情况及其影响。先前的研究表明，它可能是头颈部鳞状细胞癌（HNSCC）的一个风险因素。
方法
对头颈部癌症患者（N = 56）和无癌对照者（N = 90）进行了幽门螺杆菌的血清学检测、快速尿素酶试验和定量聚合酶链反应（qPCR）。采用逻辑回归分析对两组进行比较。
结果
在逻辑回归分析中，两组的血清学阳性率和快速尿素酶试验阳性率无差异（分别为p = 0.677和p = 0.633）。出生在发展中国家和年龄超过50岁是血清学阳性的预测因素（分别为p < 0.001和p = 0.040）。使用qPCR，没有活检显示存在幽门螺杆菌。
结论
本研究对幽门螺杆菌可能是HNSCC风险因素这一概念提出了质疑。
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