Department of Otolaryngology, St. Martin De Porres Hospital, Chiayi, Taiwan.
Department of Otolaryngology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Sci Rep. 2021 Mar 18;11(1):6229. doi: 10.1038/s41598-021-85598-4.
It remained inconclusive whether patients with peptic ulcer disease had a higher risk of head and neck cancer (HNC). Therefore, we enrolled 109,360 patients with peptic ulcer disease and matched for age and sex with 218,720 controls from the Taiwan National Health Insurance Research Database between January 1, 1997 and December 31, 2013.The HNC incidence rate was 1.33-fold higher in the peptic ulcer group than in the control group (7.52 vs. 5.68 per 100,00 person-years; crude relative risk: 1.33; 95% confidence interval [CI]: 1.08-1.63) after > 6 years of follow-up. However, in the peptic ulcer subgroup with H. pylori treatment, HNC risk was not significantly different from that of the control group (crude relative risk: 1.12; 95% CI: 0.86-1.46). Moreover, the population with peptic ulcers had the highest risk of laryngeal and hypopharyngeal cancer (adjusted HR: 2.27 [95% CI: 1.16-4.44] and 2.00 [95% CI, 1.13-3.55]), respectively. This observational study suggested that peptic ulcer disease is associated with an increased incidence of laryngeal and hypopharyngeal cancer and H. pylori treatment may have a role in preventing HNC in patients with peptic ulcer disease.
消化性溃疡患者发生头颈部癌症（HNC）的风险是否更高，结论尚不明确。因此，我们从台湾全民健康保险研究数据库中纳入了 1997 年 1 月 1 日至 2013 年 12 月 31 日期间 109360 例消化性溃疡患者，并按年龄和性别与 218720 例对照进行了匹配。经过 >6 年的随访，消化性溃疡组的 HNC 发生率是对照组的 1.33 倍（7.52 比 5.68/10 万患者年；粗相对风险：1.33；95%置信区间[CI]：1.08-1.63）。然而，在接受 H. pylori 治疗的消化性溃疡亚组中，HNC 风险与对照组无显著差异（粗相对风险：1.12；95%CI：0.86-1.46）。此外，患有消化性溃疡的人群发生喉癌和下咽癌的风险最高（调整后的 HR：2.27[95%CI：1.16-4.44]和 2.00[95%CI，1.13-3.55]）。这项观察性研究表明，消化性溃疡病与喉癌和下咽癌的发病率增加有关，H. pylori 治疗可能在预防消化性溃疡病患者的 HNC 中发挥作用。
