Burduk Paweł K
Katedra i Klinika Otolaryngologii CM im. L. Rydygiera w Bydgoszczy UMK w Toruniu.
Otolaryngol Pol. 2006;60(4):521-3.
Helicobacter pylori causes different chronic infections that has been linked to the development of malignant disease of the aerodigestive tract. The larynx as a part of upper aerodigestive tract could be infected with this bacteria, mostly by gastroesophageal reflux.
In our study rapid urease tests were performed on the tissue samples of 80 patients with laryngeal squamous cell carcinoma and 34 control with benign laryngeal pathology.
In the evaluation of 80 specimens with laryngeal cancer in 62.5% we recorded a positive urease test reaction pointing for coexisting Helicobacter pylori infection and in 37.8% of cases the negative reaction. In the control group a positive reaction was in 47.3% of cases and negative in 52.7% of cases.
Inflammation inducted by Helicobacter pylori would cause epithelial cell proliferation and could follow to development of laryngeal cancer. Thus, laryngeal tissue can be colonized by some other agents containing a urease enzyme other than Helicobacter pylori an additional tests may be performed. In our future investigation we are trying to estimate the Helicobacter pylori infection in pathologic tissue using a polymerase chain reaction (PCR).
幽门螺杆菌会引发不同的慢性感染，这些感染与上消化道恶性疾病的发展有关。喉部作为上消化道的一部分，可能会被这种细菌感染，主要是通过胃食管反流。
在我们的研究中，对80例喉鳞状细胞癌患者的组织样本以及34例患有良性喉部病变的对照者进行了快速尿素酶试验。
在对80份喉癌标本的评估中，62.5%的标本尿素酶试验反应呈阳性，表明存在幽门螺杆菌感染，37.8%的病例反应为阴性。在对照组中，47.3%的病例反应为阳性，52.7%的病例反应为阴性。
幽门螺杆菌引发的炎症会导致上皮细胞增殖，并可能继而发展为喉癌。因此，除幽门螺杆菌外，喉部组织可能会被其他含有尿素酶的病原体定植，可能需要进行额外的检测。在我们未来的研究中，我们试图使用聚合酶链反应（PCR）来评估病理组织中的幽门螺杆菌感染情况。
