Cogliati Dezza I, Zito G, Tomasevic L, Filippi M M, Ghazaryan A, Porcaro C, Squitti R, Ventriglia M, Lupoi D, Tecchio F
Laboratory of Electrophysiology for Translational NeuroScience (LET'S), ISTC, National Research Council (CNR), Unità MEG, Fatebenefratelli Hospital, Isola Tiberina, Rome, 00186, Italy.
J Neurol. 2015 Mar;262(3):614-22. doi: 10.1007/s00415-014-7590-6. Epub 2014 Dec 19.
Fatigue in multiple sclerosis (MS) is a highly disabling symptom. Among the central mechanisms behind it, an involvement of sensorimotor networks is clearly evident from structural and functional studies. We aimed at assessing whether functional/structural balances of homologous sensorimotor regions-known to be crucial for sensorimotor networks effectiveness-decrease with MS fatigue increase. Functional connectivity measures at rest and during a simple motor task (weak handgrip of either the right or left hand) were derived from primary sensorimotor areas electroencephalographic recordings in 27 mildly disabled MS patients. Structural MRI-derived inter-hemispheric asymmetries included the cortical thickness of Rolandic regions and the volume of thalami. Fatigue symptoms increased together with the functional inter-hemispheric imbalance of sensorimotor homologous areas activities at rest and during movement, in absence of any appreciable parenchymal asymmetries. This finding supports the development of compensative interventions that may revert these neuronal activity imbalances to relieve fatigue in MS.
多发性硬化症（MS）中的疲劳是一种极具致残性的症状。在其背后的中枢机制中，感觉运动网络的参与从结构和功能研究中清晰可见。我们旨在评估同源感觉运动区域的功能/结构平衡（已知对感觉运动网络的有效性至关重要）是否会随着MS疲劳的增加而降低。对27名轻度残疾的MS患者，从初级感觉运动区脑电图记录中得出静息状态和简单运动任务（右手或左手轻度握力）期间的功能连接测量值。基于结构MRI得出的半球间不对称性包括中央沟区域的皮质厚度和丘脑体积。在没有任何明显实质不对称的情况下，疲劳症状与静息和运动期间感觉运动同源区域活动的功能半球间失衡一同增加。这一发现支持开发补偿性干预措施，这些措施可能会扭转这些神经元活动失衡，以缓解MS中的疲劳。
