PEDOT 纳米复合材料介导的近红外 I 区和 II 区双模态光动力和光热靶向杀菌作用。
PEDOT nanocomposites mediated dual-modal photodynamic and photothermal targeted sterilization in both NIR I and II window.
机构信息
Department of Chemistry, Capital Normal University, Beijing 100048, PR China; Department of Chemistry, Renmin University of China, Beijing 100872, PR China.
Department of Chemistry, Capital Normal University, Beijing 100048, PR China.
出版信息
Biomaterials. 2015 Feb;41:132-40. doi: 10.1016/j.biomaterials.2014.10.075. Epub 2014 Dec 5.
PEDOT nanoparticles with a suitable nanosize of 17.2 nm, broad adsorption from 700 to 1250 nm, and photothermal conversion efficiency (η) of 71.1%, were synthesized using an environmentally friendly hydrothermal method. Due to the electrostatic attraction between indocyanine green (ICG) and PEDOT, the stability of ICG in aqueous solution was effectively improved. The PEDOT nanoparticles modified with glutaraldehyde (GTA) targeted bacteria directly, and MTT experiments demonstrated the low toxicity of PEDOT:ICG@PEG-GTA in different bacteria and cells. Pathogenic bacteria were effectively killed by photodynamic therapy (PDT) and photothermal therapy (PTT) with PEDOT:ICG@PEG-GTA in the presence of near-infrared (NIR) irradiation (808 nm for PDT, and 1064 nm for PTT). The combination of the two different bacteriostatic methods was significantly more effective than PTT or PDT alone. The obtained PEDOT:ICG@PEG-GTA may be used as a novel synergistic agent in combination photodynamic and photothermal therapy to inactivate pathogenic bacteria in both the NIR I and II window.
采用环境友好的水热法合成了具有适宜纳米尺寸 17.2nm、700-1250nm 宽吸收和 71.1%光热转换效率（η）的PEDOT 纳米粒子。由于吲哚菁绿（ICG）和 PEDOT 之间的静电吸引，ICG 在水溶液中的稳定性得到了有效提高。戊二醛（GTA）修饰的 PEDOT 纳米粒子直接靶向细菌，MTT 实验表明 PEDOT：ICG@PEG-GTA 在不同细菌和细胞中的毒性较低。在近红外（NIR）照射（PDT 为 808nm，PTT 为 1064nm）下，PEDOT：ICG@PEG-GTA 通过光动力疗法（PDT）和光热疗法（PTT）有效地杀死了致病菌。两种不同抑菌方法的结合比单独的 PTT 或 PDT 更有效。所得的 PEDOT：ICG@PEG-GTA 可作为一种新型协同剂，结合光动力和光热疗法，在 NIR I 和 II 窗口中灭活致病菌。
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