Yang Yang, Lyu Mng, Li Jing-Hua, Zhu Dao-Ming, Yuan Yu-Feng, Liu Wei
Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University Wuhan Hubei 430072 China
Medical Science Research Center, Zhongnan Hospital of Wuhan University Wuhan Hubei 430071 China.
RSC Adv. 2019 Oct 17;9(57):33378-33387. doi: 10.1039/c9ra05649a. eCollection 2019 Oct 15.
Nanoparticles working in the NIR-II biowindows possess larger maximum permissible exposure (MPE) and desirable penetration depth to the laser. However, most NIR-II responsive nanomaterials lack tumor targeting and Magnetic Resonance Imaging (MRI) ability. This greatly limits their applications. This study reported ultra-small bimetallic iron-palladium (FePd) nanoparticle loaded macrophages for targeted tumor photothermal therapy in NIR-II biowindows and magnetic resonance imaging. The crystal phase, morphology, absorption spectrum and photothermal performance of the synthesized samples were systematically characterized. The effects of photothermal therapy and nuclear magnetic imaging (MRI) were studied both and . Since FePd nanoparticles have both iron and palladium elements, it had a good MRI imaging capability and high photothermal conversion efficiency (36.7%). After binding to macrophages, FePd nanoparticles@macrophages (FePd@M) showed a good tumor targeting ability and were used for targeting NIR-II photothermal therapy and MRI imaging of tumors. The results of photothermal treatment showed that the tumor volume decreased by 90% compared to the control group, and no significant organ toxicity was observed. The results of MRI imaging showed that the FePd@M has the best imaging effect. The nanoparticles with the excellent NIR-II PTT ability and MRI effect have overcome the problem of tumor targeting and avoid the rapid removal of ultra-small nanoparticles. The FePd@M delivery system provides new ideas for material construction in the NIR-II region and has great clinical application potential.
在近红外二区生物窗口工作的纳米粒子具有更大的最大允许暴露量（MPE）和理想的激光穿透深度。然而，大多数近红外二区响应性纳米材料缺乏肿瘤靶向性和磁共振成像（MRI）能力。这极大地限制了它们的应用。本研究报道了负载超小双金属铁钯（FePd）纳米粒子的巨噬细胞用于近红外二区生物窗口中的靶向肿瘤光热治疗和磁共振成像。对合成样品的晶相、形态、吸收光谱和光热性能进行了系统表征。研究了光热治疗和核磁共振成像（MRI）的效果。由于FePd纳米粒子同时含有铁和钯元素，它具有良好的MRI成像能力和高光热转换效率（36.7%）。与巨噬细胞结合后，FePd纳米粒子@巨噬细胞（FePd@M）表现出良好的肿瘤靶向能力，并用于肿瘤的靶向近红外二区光热治疗和MRI成像。光热治疗结果表明，与对照组相比，肿瘤体积减小了90%，且未观察到明显的器官毒性。MRI成像结果表明，FePd@M具有最佳的成像效果。具有优异近红外二区光热治疗能力和MRI效果的纳米粒子克服了肿瘤靶向问题，避免了超小纳米粒子的快速清除。FePd@M递送系统为近红外二区区域的材料构建提供了新思路，具有巨大的临床应用潜力。
