Syahrom Ardiyansyah, Abdul Kadir Mohammed Rafiq, Harun Muhamad Nor, Öchsner Andreas
Sport Innovation and Technology Center (SITC), Universiti Teknologi MalaysiaJ, Johor, Malaysia.
Medical Device Technology Group, Faculty of Biomedical Engineering and Health Science, Universiti Teknologi Malaysia, Johor, Malaysia.
Med Eng Phys. 2015 Jan;37(1):77-86. doi: 10.1016/j.medengphy.2014.11.001. Epub 2014 Dec 16.
Artificial bone is a suitable alternative to autografts and allografts, however their use is still limited. Though there were numerous reports on their structural properties, permeability studies of artificial bones were comparably scarce. This study focused on the development of idealised, structured models of artificial cancellous bone and compared their permeability values with bone surface area and porosity. Cancellous bones from fresh bovine femur were extracted and cleaned following an established protocol. The samples were scanned using micro-computed tomography (μCT) and three-dimensional models of the cancellous bones were reconstructed for morphology study. Seven idealised and structured cancellous bone models were then developed and fabricated via rapid prototyping technique. A test-rig was developed and permeability tests were performed on the artificial and real cancellous bones. The results showed a linear correlation between the permeability and the porosity as well as the bone surface area. The plate-like idealised structure showed a similar value of permeability to the real cancellous bones.
人工骨是自体骨和异体骨的合适替代品，然而其应用仍然有限。尽管关于其结构特性有大量报道，但人工骨的渗透性研究相对较少。本研究聚焦于理想化的、结构化的人工松质骨模型的开发，并将其渗透值与骨表面积和孔隙率进行比较。按照既定方案提取并清理新鲜牛股骨的松质骨。使用微计算机断层扫描（μCT）对样本进行扫描，并重建松质骨的三维模型用于形态学研究。然后通过快速成型技术开发并制造了七个理想化的、结构化的松质骨模型。开发了一个试验装置，并对人工和真实的松质骨进行了渗透性测试。结果表明渗透性与孔隙率以及骨表面积之间存在线性关系。板状理想化结构显示出与真实松质骨相似的渗透值。
