Department of Solid Mechanics and Design, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, Johor, Malaysia.
Med Eng Phys. 2013 Jun;35(6):792-9. doi: 10.1016/j.medengphy.2012.08.011. Epub 2012 Sep 7.
In the development of artificial cancellous bones, two major factors need to be considered: the integrity of the overall structure and its permeability. Whilst there have been many studies analysing the mechanical properties of artificial and natural cancellous bones, permeability studies, especially those using numerical simulation, are scarce. In this study, idealised cancellous bones were simulated from the morphological indices of natural cancellous bone. Three different orientations were also simulated to compare the anisotropic nature of the structure. Computational fluid dynamics methods were used to analyse fluid flow through the cancellous structures. A constant mass flow rate was used to determine the intrinsic permeability of the virtual specimens. The results showed similar permeability of the prismatic plate-and-rod model to the natural cancellous bone. The tetrakaidecahedral rod model had the highest permeability under simulated blood flow conditions, but the plate counterpart had the lowest. Analyses on the anisotropy of the virtual specimens showed the highest permeability for the horizontal orientation. Linear relationships were found between permeability and the two physical properties, porosity and bone surface area.
在人工松质骨的开发中，需要考虑两个主要因素：整体结构的完整性及其渗透性。虽然已经有许多研究分析了人工和天然松质骨的力学性能，但渗透性研究，特别是使用数值模拟的研究却很少。在这项研究中，从天然松质骨的形态学指标中模拟出理想的松质骨。还模拟了三种不同的方向，以比较结构的各向异性。使用计算流体动力学方法分析了通过松质结构的流体流动。使用恒定的质量流量来确定虚拟样本的固有渗透率。结果表明，棱柱板和杆模型的渗透率与天然松质骨相似。在模拟血流条件下，十四面体杆模型的渗透性最高，但对应的板模型的渗透性最低。对虚拟样本各向异性的分析表明，水平方向的渗透性最高。发现渗透率与两个物理性质（孔隙率和骨表面积）之间存在线性关系。
