School of Chemistry and Chemical Engineering, Qinghai Nationalities University, Xining, China.
School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
PLoS One. 2021 Mar 4;16(3):e0247764. doi: 10.1371/journal.pone.0247764. eCollection 2021.
In this paper, we take the elliptical pore structure which is similar to the microstructure of cancellous bone as the research object, four groups of bone scaffolds were designed from the perspective of pore size, porosity and pore distribution. The size of the all scaffolds were uniformly designed as 10 × 10 × 12 mm. Four groups of model samples were prepared by selective laser melting (SLM) and Ti6Al4V materials. The statics performance of the scaffolds was comprehensively evaluated by mechanical compression simulation and mechanical compression test, the manufacturing error of the scaffold samples were evaluated by scanning electron microscope (SEM), and the permeability of the scaffolds were predicted and evaluated by simulation analysis of computational fluid dynamics (CFD). The results show that the different distribution of porosity, pore size and pores of the elliptical scaffold have a certain influence on the mechanical properties and permeability of the scaffold, and the reasonable size and angle distribution of the elliptical pore can match the mechanical properties and permeability of the elliptical pore scaffold with human cancellous bone, which has great potential for research and application in the field of artificial bone scaffold.
本文以类似松质骨微观结构的椭圆形孔隙结构为研究对象，从孔径、孔隙率和孔隙分布的角度设计了四组骨支架。所有支架的尺寸均均匀设计为 10×10×12mm。通过选择性激光熔化（SLM）和 Ti6Al4V 材料制备了四组模型样品。通过机械压缩模拟和机械压缩试验综合评价了支架的静力学性能，通过扫描电子显微镜（SEM）评价了支架样品的制造误差，并通过计算流体动力学（CFD）的模拟分析预测和评价了支架的渗透性。结果表明，不同分布的孔隙率、孔径和椭圆形支架的孔隙对支架的力学性能和渗透性有一定的影响，合理的椭圆形孔隙的大小和角度分布可以使椭圆形孔隙支架的力学性能和渗透性与人的松质骨相匹配，在人工骨支架领域具有很大的研究和应用潜力。
