Nascimento Dahan da Cunha, Navalta James Wilfred, Durigan João Luiz Quagliotti, Marqueti Rita de Cassia, Tibana Ramires Alsamir, Luiz Franco Octavio, de Almeida Jesser Alves, Camarço Nathalia Ferreira, Neto Ivo Vieira de Sousa, Prestes Jonato
Graduate Program on Physical Education, Catholic University of Brasilia, Brasilia, Brazil.
Kinesiology and Nutrition Sciences, University of Nevada, Las Vegas, NV, USA.
Clin Physiol Funct Imaging. 2016 Mar;36(2):139-45. doi: 10.1111/cpf.12207. Epub 2014 Dec 18.
The association of ageing with obesity commits elderly women and has been correlated with multiple degenerative processes, which could be occasioned by an enhancing in levels of matrix metalloproteinase-2 and metalloproteinase-9 (MMPs) as well by an cytokine unbalance that included an enhancing on interleukin-6 (IL-6). Furthermore, other factors could be also related to degenerative process, as they could be reduced by eccentric resistance exercise (ERE), which seems particularly important to initiate resistance training in obese older adults. In this view, this study aims to determinate the effects of an acute ERE session on serum MMP-2, MMP-9 and IL-6 in elderly obese women. Ten elderly obese women participated in this study and completed a 10 repetitions maximum test (10 RM) utilizing leg extension exercise. Subjects then completed an acute ERE session consisting of seven sets of 10 repetitions at 110% of 10 RM with a rest of 3 min between sets. Blood samples were collected before, immediately after, 3, 24 and 48 h following the ERE session. Zymograms were utilized to measure the MMP-2 and MMP-9 enzymes from all individuals. Moreover, IL-6 concentration was also determinated. After ERE session, MMP-2 and MMP-9 decreased, remaining significantly below baseline values after 48 h (P<0·05). Although not statistically significant, there was a tendency for IL-6 to decrease 48 h after the ERE when compared with 3 h (P = 0·06). An acute ERE session decreases MMP-9, MMP-2 and IL-6 in elderly obese women, possibly indicating a transient protection against the low grade inflammation present in this specific population.
衰老与肥胖的关联对老年女性不利，且与多种退行性过程相关，这可能是由基质金属蛋白酶-2和金属蛋白酶-9（MMPs）水平升高以及包括白细胞介素-6（IL-6）升高在内的细胞因子失衡所引起的。此外，其他因素也可能与退行性过程有关，因为它们可以通过离心阻力运动（ERE）而降低，这对于肥胖老年人开始进行阻力训练似乎尤为重要。有鉴于此，本研究旨在确定一次急性ERE训练对老年肥胖女性血清MMP-2、MMP-9和IL-6的影响。十名老年肥胖女性参与了本研究，并通过腿部伸展运动完成了一次最大重复次数为10次的测试（10RM）。受试者随后完成了一次急性ERE训练，包括七组，每组10次重复，强度为10RM的110%，组间休息3分钟。在ERE训练前、训练结束后立即、训练后3小时、24小时和48小时采集血样。利用酶谱法测量所有个体的MMP-2和MMP-9酶。此外，还测定了IL-6的浓度。在ERE训练后，MMP-2和MMP-9降低，在48小时后仍显著低于基线值（P<0·05）。尽管无统计学意义，但与3小时相比，ERE训练后48小时IL-6有降低的趋势（P = 0·06）。一次急性ERE训练可降低老年肥胖女性的MMP-9、MMP-2和IL-6，这可能表明对该特定人群中存在的低度炎症有短暂的保护作用。
